Really
Not
Awake
Not
Awake
This drug inhibits RNA polymerase in prokaryotes to block transcription.
BONUS+100: What disease does this drug treat
Rifampin
BONUS: Tuberculosis
What is this nomenclature describing?
p.G542_A543insDW
An insertion of aspartate and tryptophan between glycine at position 542 and alanine at position 543
This second messenger is involved in expression of the lac operon in the absence of glucose and is this type of ligand
BONUS+100: Name the protein it binds to for expression
cAMP/Co-Activator
BONUS: CAP (Catabolite Activator Protein)
This diagnostic method is used to detect insertions or deletions between restriction sites
BONUS+100: Name a disease typically diagnosed using this method
RFLP (Restriction Fragment Length Polymorphism)
BONUS: Sickle Cell Anemia
This disease presents with increased aging and usually death by the age of 13
BONUS+100: Name the protein that is defective in this disease
Hutchinson-Gilford Progeria Syndrome
BONUS: Lamin A
This process involves formation of a hairpin structure due to GC rich palindrome sequences
Rho-Independent Termination
This disease is due to mismatch repair mutations
BONUS+100: Name the genes involved
Hereditary Nonpolyposis Colorectal Cancer
BONUS: MSH2 & MLH1
BONUS: This protein is translated in an environment with high iron
BONUS: Ferritin
This disease presents with short stature, cardiac defects, hypotonia, and brain abnormalities
BONUS+100: Name the diagnostic method used to detect this disease
DiGeorge Syndrome
BONUS: Metaphase FISH
True or False: Ran-GTP is hydrolyzed by Ran GEF to remove the phosphate group in the cytoplasm
False
What are the classes of RNA's produced from these polymerases?
RNA Polymerase I
RNA Polymerase II
RNA Polymerase III
rRNA
mRNA/miRNA
tRNA
UV radiation results in this kind of DNA damage
pyrimidine dimers
Mediator Protein
A 4-year old patient is brought in with multiple anomalies with no known origin. This diagnostic test is best used when there is no obvious syndrome
BONUS+200: Name the anomalies this test is specifically used to detect
CGH (Comparative Genome Hybridization)
BONUS: Deletions & Duplications
This compound is found in lung surfactant
BONUS+100: What percentage of surfactant is made of this compound
Phosphatidylcholine (& Phosphatidylglycerol)
BONUS: 80%
This protein binds to the INR sequence and TATA box to initiate transcription
BONUS +100: Name the subunit that binds directly to the TATA Box
TFIID
BONUS: TBP (TATA-Binding Protein)
This type of DNA repair is needed to remove uracil due to deamination of cytosine
BONUS+200: Name the enzyme involved with this particular process
Base Excision Repair
BONUS: Uracil DNA Glycosylase
Once a steroid receptor binds to its respective steroid hormone, list the process that occurs afterward.
i. Form homodimer
ii. Translocate to nucleus
iii. Bind response-elements
iv. Activates or represses transcription
These types of sequences are used as genomic markers because they are highly polymorphic.
BONUS+100: What type of diagnostic test typically uses these sequences?
VNTR (Variable Number Tandem Repeats)
BONUS: DNA Fingerprinting
In normal physiologic conditions increasing this will result in a decrease in fluidity
Cholesterol
7-methylguanosine cap (5' Cap) and Polyadenylation signal (PolyA Tail)
This disease involves the over expression of helicase due to excessive sister chromatid exchange
BONUS+100: Name the mode of inheritance
Bloom Syndrome
BONUS: Autosomal Recessive
This protein is involved in translation of globins and is unstable in its inactive form
BONUS+200: Name the factors needed for activation of this protein
eIF-2
BONUS: Heme and Fe2+
ASO Hybridization
This disease is described as abnormally shaped RBC's and results in splenomegaly, reticulocytosis, and hyperbilirubinemia.
BONUS+200: What most often causes this disease?
Hereditary Spherocytosis
BONUS: Defect in Spectrin Protein