B cells
What are the different types of naïve mature B cells?
What are B1, B2, and Marginal Zone B cells
Does the heavy or light chain of antibodies have a D segment?
What is heavy chain?
What is the location where gene rearrangement take place for T cells?
What is the thymus?
What does CAR stand for?
What is Chimeric Antigen Receptor?
What family of cytokines is characterized by the presence of a four-helix bundle motif in its structure?
What are Hematopoietin (Class I) Cytokines?
What is the difference between TI-1 Ag and TI-2 Ag?
TI-1 Ag requires an extra activation signal, so the BCR binds to the Ag and PRR (TLR4/LPS). TI-2 Ag has cross-linking occurs so multiple BCRs bind and have extended activation signal.
What enzyme is responsible for isotype switching?
What is AID?
MHC Class II binds to which T-cell coreceptor?
What is CD4?
Why did the researchers perform ex vivo studies with TNBC cells and spheroid organoids?
What is Ex vivo studies allowed the researchers to mimic a human clinical setting. These models create the closest representations to the likely tumor microenvironment of a TNBC solid tumor in a human patient?
Which Interferon type is produced by cells associated with the adaptive immune system?
What is type II?
What type of B cell cancer impacts the lymph nodes and spleen?
What are B-cell lymphomas?
Name the isotype that is protease resistant, and describe its location and at least one of its effector functions
What is IgA; Found in mucosa of the gut, reproductive tract, and lungs as well as fluid secretions; Effective at neutralizing toxins and pathogens (little opsonization and complement)
Describe the 2 process that occur during thymic selection
Positive Selection-If TCR binds to MHC/Ag with low affinity, they survive
Negative selection- High binding to MHC/Ag=death by apoptosis, No binding to MHC/Ag=death by neglect
Why did the researchers also measure mice body weight in Figure 3?
What is To test if the MSLN-NK treatment would also negatively affect mice health?
The Epstein-Barr Virus's capability to have a protein that mimics IL-10 is an example of a ...
What is acting as a pathogen-derived cytokine antagonist?
What word is used to describe the signaling during the T2 positive selection stage of peripheral tolerance?
What is tonic signaling?
What type of immunoglobulin is the first response to antigen?
What is IgM?
Which cDNA clones were identified as T-Cell Specific After the Subtractive Hybridization Experiment?
What are TM90 and TM86?
What does the CCK8 cell assay allow us to test?
What is Cell viability/cytotoxicity?
What are the polarizing cytokines for T-Regulatory Cells?
What are IL-2 and TGF-β?
During V(D)J recombination, which enzyme is used to open up the hairpin structure?
What is Artemis?
What are the two important enzymes that are knocked out in a SCID mouse?
What are RAG1 and Ku70?
What transcription factor is especially active during the Single Positive stage?
What is AIRE transcription factor?
What two characteristics of iPSCs made them a usual cell to start off with in this study?
What are Have new genes delivered to them (specifically designed CAR receptor in this case) and Differentiated into a cell of interest (ex. NK!!)?
A patient is experiencing a condition consisting of an exacerbated immune response. The doctor concludes that it stems from the patient immune system's failure to immunosuppress itself. Which family of cytokines should the doctor look into?
What are Interferons (recall IL-10 is a part of IFN-gamma family)?