Movement Disorders Pharmacology
The pharmacologic goal of Parkinson's Disease therapy
What is increase dopaminergic signaling
A medication with "on" and "off" episodes that is considered to be first line monotherapy for Parkinson's Disease
What is carbidopa/levodopa (Sinemet)
What is the relationship between dopamine and cholinergic activity
What is inverse relationship
Syndrome characterized by clinically significant disturbance in cognition, emotion regulation or behavior
What is a Mental Disorder
Uncontrolled involuntary movement that occur at various times
What is Dyskinesias
A movement disorder characterized by too much dopamine signaling
What is Huntington's Disease
This medication comes with a very high risk for profound orthostatic hypotension and severe nausea/vomitting
What is Apomorphine (Apokyn)
Dysarthria, micrographia and muscle rigidity are what type of symptoms
What are motor symptoms
A tool used to assess patient behavior, insight, mood, perception, appearance, speech and cognition/thoughts
What is a Mental Status Exam
What is the effort to move mentally ill patients out of state psychiatric facilities and into the community
What is the Deinstitutionalization Movement
Carbidopa is an inhibitor of this enzyme
What is Dopamine decarboxylase
Stalevo is a combination of these three agents
What is carbidopa, levodopa and entacapone
A class of medication that could cause drug-induced parkinsonism
Antipsychotics, antiemetics, SSRIs, SNRIs, TCAs, Dopamine depleters (methyldopa, tetrabenazine, reserpine)
The guide containing diagnostic criteria for a variety of mental illnesses
What is the DSM-5
Patient demonstrates mystical thinking with
delusions about angels and devils - what category of the MSE does this fall under
What is Thought
A large portion of L-Dopa is metabolized there
What is peripherally
Reserpine is an example of what class of medication
VMAT (vesicular monoamine transporter) inhibitor
A drug-induced medical emergency characterized by excessive sweating, AMS, irregular heartbeat and muscle cramps/rigidity
What is NMS (Neuroleptic Malignancy Syndrome)
Anorexia is an example of what type of disorder
What is an Eating Disorder
An organization aimed at changing attitudes and stereotypes around people with mental illnesses
What is NAMI (National Alliance on Mental Illness)
What class of medications has no therapeutic benefit unless administered with levodopa doses
What are COMT Inhibitors
The pharmacologic class of benztropine
What is an Anticholinergic agent
Two ways to manage levodopa - induced dyskinesias
What is shortening dose intervals/decreasing dose of carbidopa/levodopa AND add on long-acting formulation of amantadine
According to DSM-IV structure, Schizophrenia falls under this axis
What is Axis 1
A setting where psychiatric illnesses are treated/managed
What is CPEP, Partial Hospitalization, Outpatient Treatment Facility, Inpatient Treatment (acute or long-term)