Kidneys
Neuro
Musculoskeletal
Wildcard
100

This pressure, one of the Starling forces, pushes fluid out of the capillaries and into the interstitial space, promoting filtration at the arterial end of capillaries.

What is capillary hydrostatic pressure?

100

Located in the anterior part of the frontal lobe, this brain region is responsible for executive functions such as decision-making, planning, judgment, personality expression, and impulse control.

What is the prefrontal cortex? 

100

Caused by repetitive motion, awkward postures, or overuse of muscles, tendons, and nerves, this group of conditions includes carpal tunnel syndrome and tendinitis, and develops gradually over time.

What are cumulative trauma disorders (CTDs)?

100
When you barely tap someone and they feel like you punched them

What is Hyperalgesia

200

In this final stage of chronic kidney disease, the loss of nearly all nephron function leads to the inability to maintain fluid, electrolyte, and waste balance, often requiring dialysis or transplantation.

What is end-stage renal disease (ESRD)?

200

After being released into the synaptic cleft, this neurotransmitter binds to receptors on the postsynaptic membrane to transmit the signal, then is broken down by acetylcholinesterase into acetate and choline, ending its action.

What is acetylcholine (ACh)?

200

It takes this length of time for a fracture to heal including final bone remodeling 

What is 1 year? 

200

When I touched them with a cotton swab and it felt painful 

What is Allodynia 

300

When levels of antidiuretic hormone, also known as arginine vasopressin (AVP), increase, this renal response occurs—resulting in water reabsorption in the collecting ducts and a more concentrated urine.

What is increased water reabsorption and decreased urine output?

300

Normal motor function depends on a delicate balance between these two neurotransmitters in the basal ganglia—one that facilitates movement and another that inhibits it.

What are dopamine and acetylcholine? 

(Dopamine promotes smooth, purposeful movement, while acetylcholine provides counterbalance. An imbalance—such as dopamine loss in Parkinson’s disease—leads to motor dysfunction.)

300

This common knee injury in athletes, especially football players, often causing pain, swelling, locking, or clicking of the knee joint after a twisting motion, usually in a semi flexed weight bearing position. 

What is a meniscus tear? 

300

When you rub you elbow when you bump it 

What is gate theory of pain 

400

Released by ventricular myocytes in response to volume expansion and increased pressure, this peptide promotes natriuresis, diuresis, and vasodilation to reduce blood volume and blood pressure.

What is B-type natriuretic peptide (BNP)?

400

In response to pain signals, this neurotransmitter is released from neurons in the descending spinal pathways, helping to inhibit pain transmission by modulating nociceptive signals in the dorsal horn of the spinal cord.

What is norepinephrine?

400

 A herniated disc at this thoracic spinal level can cause pain or sensory changes around the upper chest and back, following the T3 dermatome, but typically does not radiate to the fingers.

What is a herniated disc at T3?

400

Produced in the lateral hypothalamus, this neuropeptide promotes wakefulness and arousal by stimulating the reticular activating system and maintaining alertness.

What is Orexin? 

500

By inhibiting sodium and chloride reabsorption in the distal convoluted tubule, this class of diuretics reduces plasma volume, leading to decreased edema and lower blood pressure.

What is a thiazide diuretic 

500

These types of receptors decrease the likelihood that a neuron will fire an action potential, often by causing hyperpolarization through the influx of chloride ions or efflux of potassium ions. Examples include GABAA_AA and glycine receptors.

What are inhibitory receptors? 

500

These multinucleated cells derived from the monocyte–macrophage lineage are activated by RANKL and inhibited by osteoprotegerin, and their overactivity—seen in conditions like **hyperparathyroidism, metastatic bone disease, and osteoporosis—**leads to pathologic bone resorption and weakening of the skeletal matrix.

What is an osteoclast?

500

In generalized anxiety disorder, hyperactivity of this limbic structure amplifies emotional responses to perceived threats, leading to excessive fear, worry, and autonomic arousal, while impaired regulation from the prefrontal cortex fails to inhibit its activity.

What is the amygdala?

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