All of Us/ Pharmgkb/ Nomenclature
True or False: The All of Us Research Project is a clinical trial.
False, it's not a clinical trial
A) Lower
B) Higher
A) Lower
True or False: 30% of African Americans and 50% whites express high levels of CYP3A5.
False- 30% of Whites and 50% African Americans
CYP2C9 is the primary enzyme in warfarin PGx because:
A) it metabolizes S-warfarin
B) it metabolizes R-warfarin
A) it metabolizes S-warfarin, the potent form.
Which one of these drugs is a first line agent for diabetes?
A) Pioglitazone
B) Glimepiride
C) Metformin
C) Metformin
What metabolizer has an activity score of 1 and has two dominant alleles?
A) Poor
B) Ultra-rapid
C) Normal
C) Normal
What drug is considered the gold standard endocrine therapy for patients with estrogen receptor positive (ER+) or progesterone receptor positive (PR+) breast cancer?
A) Endoxifen
B) Estradiol
C) Tamoxifen
C) Tamoxifen
What drug is associated with neuropsychiatric symptoms and can cause QTc prolongation?
A) Abacavir (ABC)
B) Efavirenz (EFV)
C) Atazanavir (ATV)
B) Efavirenz (EFV)
What DRUG inhibits the synthesis of vitamin K-dependent coagulation factors (II, VII, IX, X) and inhibits anticoagulation proteins C & S.
A) Warfarin
B) Clopidogrel
C) Atenolol
A) Warfarin
Which of these CYP enzymes is responsible for metabolism in 2 or more PGx indications?
A) CYP2C9
B) CYP2C18
C) CYP2C8
A) CYP2C9
The database of information provided by All of Us is housed where?
A) National Library of Medicine
B) Data and Research Center (DRG)
C) LSU Research Center
B) Data and Research Center (DRG)
What 2 monoclonal antibody drugs are currently approved for treatment of colorectal cancer? (select 2)
A) Cetuximab
B) Panitumumab
C) Pertuzumab
A) Cetuximab
B) Panitumumab
What drug class blocks T-cell proliferation by inhibiting the production of IL-2 and other cytokines?
A) Calcineurin Inhibitors
B) Antimetabolites
C) mTOR Inhibitors
A) Calcineurin Inhibitors
What is the active form of clopidogrel?
A) isoenzyme
B) Sulfite
C) Thiol metabolite
C) Thiol metabolite
Which drug is associated with increased risk of heart failure?
A) Metformin
B) Pioglitazone
C) Glipizide
B) Pioglitazone
What SNP results from a missense mutation changing an amino acid?
A) Non-Synonymous
B) Premature Stop Codon
C) Synonymous
A) Non-synonymous
What is a downstream effector of EGFR?
A) GWAS
B) KRAS
C) FISH
B) KRAS
What drug class metabolizes CYP3A?
A) Calcineurin Inhibitors
B) Antimetabolites
C) mTOR Inhibitors
C) mTOR Inhibitors
What is the FDA approved test?
A) Inova
B) NIPS test
C) Amplichip CYP450
C) Amplichip CYP450
Which enzyme metabolizes Fluoxetine, Paroxetine, and Venlafaxine?
A) CYP2C9
B) CYP2D6
C) CYP2D9
B) CYP2D6
How does a non-synonymous SNP affect drug metabolism?
Changing the amino acid in the protein may change the protein's primary structure that changes the protein folding and function and leads to a chain in the drug metabolism.
What drugs are affected by the CYP2D6*5 polymorphism? (4)
SSRIs, Tamoxifen, Codeine, and Beta Blockers
Name the treatment regimen for 2 months and 4 months for Tuberculosis.
2 months: RIPE (Rifampin, Isoniazid, Pyrazinamide, & Ethambutol)
4 months: Isoniazid & Rifampin
Common indications of beta blockers? (3)
Heart failure, post MI, and hypertension
Which drug should we avoid giving patients who have a HLAB*1502 polymorphism?
Carbamazepine