Interpreting Rx Orders
Explain the difference between a prescription and a medication order?
Prescription: outpatient setting, set qty/days supply, etc
Med order: Inpatient/institutional, etc
Name 3 dosage forms that would be appropriate for PO administration.
Tablet
Capsule
Suspension
Liquid
Elixir
Solution
This law/regulation established 5 schedules for drugs subject to abuse.
Comprehensive Drug Abuse Prevention and Control Act of 1970
This chapter is used when compounding a sterile preparation.
USP <797>
This drug classification is known for its anxiolytic effects and is a controlled substance.
Benzodiazepines
Name two advantages of an eRx.
■ Reduces errors due to prescription legibility
■ Concurrent software screens for drug interactions
■ Reduces incidence of altered or forged prescriptions
■ Efficient for both prescriber and pharmacist
■ Convenience to the patient, whose prescription would likely be ready for pick-up upon arrival at the pharmacy
This dosage form involves placing the drug in the cheek.
Buccal
This document must be filed with the FDA each time a Sponsor wishes to test a new drug for clinical development
What is an IND?
The name of the document used to store information of a compound the FIRST TIME it is prepared. This is required for every compound and should be used each time the prescription is dispensed.
Master Formulation Record
The drug that is AFFECTED BY the drug interaction.
Object drug
Translate the following SIG into English:
10 mL PO 1 hr ac or 2 hrs pc bid x 7d, then 5 mL qd x 7d, then 5 mL qod.
Take 10 mL by mouth 1 hr before a meal or 2 hours after a meal twice daily for 7 days, then 5 mL daily for 7 days, then 5 mL every other day.
This is the only route of administration that provides 100% bioavailability.
IV (intravenous)
The Federal Food, Drug, and Cosmetic Act of 1938 required that new drugs show ________ in order to be approved.
(Safety, efficacy, both, neither)
Safety only
The component of the United States Pharmacopeia which contains standards for all drug substances, dosage forms, and compounded preparations.
Monograph
Name two NTI drugs
Carbamazepine
Cyclosporine
Digoxin
Ethosuximide
Flecainide
Gentamicin
Levothyroxine
Lithium
MTX
PHT
Rifampin
Theophylline
Vanco
VKA
What is the 5 rights principle?
RIGHT:
Medication
Dose
Patient
Time
Route of Admin
(1) Transdermal
(2) Topical
One goal of a Phase II clinical trial.
Determine efficacy and side effects
Dosage, regimen for phase III
Evaluation of study endpoints, therapeutic regimens, target populations
The maximum BUD and storage conditions of an oral liquid prepared using non-aqueous ingredients in a non sterile setting.
90 days at CRT or refrigerated.
Mrs. Puff is a 110 lbs patient who has received a prescription for an antibiotic. The dosing is 12 mg/kg/day, which is to be divided into 2 doses. How many mg of the antibiotic is needed per day?
Translate the following sig into English:
gtt. ii os et gtt. i od qam.
Instill 2 drops into the left eye and 1 drop into the right eye every morning.
Name two reasons why a patient may use a rectal dosage form over an oral dosage form.
No first pass effect
Unconscious/uncooperative
Cannot tolerate PO
The term used to describe when a drug product is not consistent with its FDA-approved labelling is (1) _________, whereas the contamination or inappropriate storage/handling/dispensing of a medication leading to impurities is (2) __________.
(1) Misbranding
(2) Adulteration
This category of non-sterile compounding involves preparations that are made using ingredients that require special handling (e.g., morphine suppositories, clotrimazole troches).
Moderate non-sterile compounding
This dietary supplement/vitamin may be used for insomnia. It may increase GABA activity in the CNS and has benzodiazepine-like effects.
Valerian root