500
We know that the majority of individuals diagnosed with Major Depressive Disorder (MDD) are diagnosed with an additional disorder (e.g., anxiety). However, antidepressant research tends to recruit patients with depression only. How might this decision maximize internal validity and minimize external validity?
Shows understanding that recruiting a sample with uniform psychopathology allows researchers to test that the medication (IV) works on depression as a singular disorder (DV). External validity is compromised because the degree to which the findings are generalizable to “real-world” depressed individuals (i.e., people with comorbidities) is unknown.