Antibody ID
The term for when an antibody shows varying strength reactions with homozygous and heterozygous cells
Dosage
What percentage of people are D antigen negative?
15%
Kidd antibodies cause a problem in transfusion medicine because they are notorious for what?
Disappearing/decreasing in titer until they become undetectable
Duffy blood group antigens are ______ by enzymes
Destroyed
K is the most _____ antigen after D
Immunogenic
The type of cell needed for positive QC when performing antigen phenotyping
Heterozygous
The C trans to D chromosome configuration is known to cause what?
Weak D phenotype
The population that the Jk(a-b-) phenotype is most likely to occur in
Asian, specifically of Polynesian descent
The Duffy antigens act as an entry point on the red blood cells for which pathogen?
The amoebae that cause malaria, specifically Plasmodium vivax and Plasmodium knowlesi
Kell blood group antigens are destroyed by this substance
DTT
As a general rule; heterozygous rule outs should NOT be done for these blood groups
Duffy, Kidd, MNS (Lewis)
This gene is needed in order to be able to express Rh antigens
RHAG
The transfusion reaction that Kidd antibodies are known to be implicated in
Delayed Hemolytic Transfusion Reaction
The Fy allele is a genetic variant produced by what mutation?
The GATA mutation
The McLeod phenotype is closely associated with _____, another X-linked disorder, and is know to display ______ red cell morphology on a peripheral smear
Chronic Granulomatous Disease
Acanthocytosis
Your initial panel suggests an Anti-S. You have not been able to rule out M yet. What genotype should you look for when finding additional cells to run?
S-, M+, N-
A female of childbearing age with the partial D phenotype should be treated as what for the purpose of blood donation?
Rh Positive
Kidd antigens are affected in what way when treated with enzymes?
They are enhanced
Double duffy negative individuals cannot make Anti-Fyb because
The Fy silent allele is a broken Fyb allele - Fyb is still expressed on the tissues and therefore not foreign
The McLeod phenotypes lack the _______ antigens, and has a weakened expression of ________
Lack Kx and Km
Weakened expression of all other Kell group antigens
An antibody workup suggests both an Anti-K and Anti-Fya on a patient with no history. In order to get the required rule-INs for the Anti-K, you need 3 reagent cells with _____ genotype that have a positive reaction with the patient's plasma
K+, Fya -
(zygosity of K/k doesn't matter)
What is the most likely Rh haplotype combo for the following antigen phenotype in a Caucasian person?
1, -2, 3, 4, 5
R2r
The red cells of individuals with the Kidd null phenotype have the unique ability to resist lysis by this substance
2M urea
Finding red cell products for someone with an Anti-Fy3 does not pose a problem because
~60% of people of African descent have that phenotype
The Kellnull phenotype is capable of producing Anti-Ku, an antibody that targets _________
All Kell group antigens EXCEPT Kx