Serious Muscle Memory
What is the percentage of fewer false positives based on the AChrR-Bi reflex to AChR-Mo?
45%
What is number of times MOG antibodies are more likely to be positive in pediatric patients than AQP4 antibodies?
11
What is the objective of the Paraneoplastic Evolution?
Shift physicians from ordering a paraneoplastic evaluation to PSEs.
What is the recommendation when results for PT217 fall in intermediate zone?
Confirm with CSF or amyloid PET
What antibodies don't respond to typical treatment (IVIG)?
NF155 and Contactin 1
What are the benefits of MUSK reflex?
Single blood draw, single order, reduces ordering confusion.
What is the frequency of AQP4 antibodies in NMOSD phenotype?
80%
Why does MCL include antibodies in our evaluations?
They are clinically relevant or actionable, i.e. leads to a definitive diagnosis, directs a search for cancer, guides treatment/established treatment response.
What is the accuracy, specificity and sensitivity of PT 217 assay?
93%, 96% and 92% respectively.
What is MCL's recommended approach before ordering?
Nerve conduction study results
What is the specificity MGMR achieves with the addition of an AChR-Mo reflex when AChR-Bi is positive?
95%
What is the specificity of MCL's AQP4 IgG FACS live cell based assay in recent study?
100%
For which phenotypes does the APE2 scorecard apply?
Encephalopathy, epilepsy, dementia, pediatric CNS disorders.
What is the ratio measured in our Alzheimer's disease evaluation ADEVL?
p-tau181/AB42
Which type of PN is more likely to be paraneoplastic?
Autoimmune axonal neuropathy
What is the approximate percentage of cases associated with thymoma for MG positive patients?
10-30%
What is the number of cases that could potentially be missed with a fixed CBA for MOG IgG?
~50%
Which antibodies should be ordered as standalone because not yet incorporated into our evaluations?
GABA-A,Ma2 and Kelch-11
What is AMYR?
The FDA-approved amyloid pathology test offered by MCL that measures the AB42/AB40 ratio.
What is the approach to ordering that we are trying to shift providers away from and towards?
Avoid ordering based on sensory, motor and sensorimotor symptoms and order based on the results of EMG/NCV.