Systemic Fungal Drugs
Azole Antifungals
Superficial Antifungals
Protozoan/Nonprotozoan Drugs
Helminthic Infections
100
broad spectrum of activity and effective against most fungi pathogenic to humans
What is Amphotericin B?
100
interferes with synthesis of ergosterol
What is mechanism of action?
100
common locations of superficial fungal infections
What is hair, scalp, nails and mucous membranes?
100
caused by four species of the protozoan Plasmodium?
What is malaria?
100
Classified as
What is roundworms (nematodes), flukes (trematodes) or tapeworms (cestodes)?
200
Prophylactic antifungal therapy in patients
What is severe immunosuppression?
200
Able to reach infections in various body systems
What is CNS, bone, eye, urinary tract and respiratory tract?
200
Occur in any patient vs. pt with immunosuppression
What is superficial vs. systemic fungal infection?
200
are goals of antimalarial therapy
What is prevention of the disease, treatment of acute attacks and prevention of relapse?
200
most common helminth infection in the U.S.
What is Enterobius vermicularis?
300
to reduce toxicity
What is has been formulated with several lipid molecules?
300
A Major disadvantage to drug therapy with Fluconazole
What is relatively narrow spectrum of activity?
300
topical antifungal
What is Nystatin?
300
Primary antimalarial agent
What is Chloroquine?
300
most widely prescribed anthelmintic in the U.S.
What is Mebendazole (Vermox)?
400
Observed in 80% of patients taking Amphotericin B
What is nephrotoxicity?
400
immunosuppression
What is Stevens-Johnson syndrome?
400
cream, ointment, powder, tablet and lozenge
What is available in a wide variety of formulations?
400
includes sx of blurred vision, photophobia and difficulty focusing
What is retinal toxicity?
400
poorly absorbed
What is after oral administration?
500
important lab tests
What is Serum Cr, alk phos, BUN, AST, ALT, K+, Ca++ and Mg?
500
Increased risk for bleeding
What is use of fluconazole and warfarin concurrently?
500
related to preservatives found in some formulations
What is contact dermatitis?
500
disrupts nucleic acid synthesis
What is Metronidazole (Flagyl)?
500
pinworms vs. other infections
What is single dose vs. 3 consecutive days of therapy?
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