Final Jeopardy
These may be included in the workup for pregnancy loss, guided by the patient's medical history (4/7).
Karyotyping and/or microarray of POC
Paternal karyotyping
A1C
TSH
Prolactin
Uterine cavity assessment
Acquired thrombophilia testing (APS)
This is the most effective method of treatment for early pregnancy loss.
What is surgical management?
This is the single most common numerical chromosome abnormality identified among abortuses.
What is monosomy X (Turner's syndrome)
Prenatal ultrasound findings for this condition may include cystic hygroma, generalized edema, coarctation of the aorta.
What is monosomy X (Turner's syndrome)?
These three laboratory values are assessed in the workup for antiphospholipid syndrome.
What are lupus anticoagulant, anticardiolipin, and beta-2-glycoprotein?
All patients who experience pregnancy loss should be evaluated for candidacy to receive this medication to reduce the risks of alloimmunization in future pregnancies.
What is rhogam?
This is the single most common trisomy identified among abortuses.
What is trisomy 16?
What is a septate uterus?
These abnormal findings can not be considered causative for pregnancy loss in the setting of an aneuploid pregnancy.
What are mullerian anomalies?
Medical management of early pregnancy loss can be accomplished with regimens including these two medications.
What are mifepristone and misoprostol?
This is the most common genetic abnormality implicated in recurrent pregnancy loss affecting 2-3% of couples with recurrent miscarriage.
What is a chromosomal translocation?
This chromosomal rearrangement involves the fusion of the long arms of two acrocentric chromosomes, with loss of the remaining short arms.
What is a Robertsonian translocation?
This specimen source is most likely to produce a result on karyotype following a late pregnancy loss.
What is amniotic fluid (~80%)?
Fetal tissue after delivery is insufficient in 50-75% of cases.
Anticoagulation with low dose aspirin and prophylactic heparin improves pregnancy outcomes in patients with recurrent pregnancy loss and this syndrome.
What is antiphospholipid syndrome?
Most trisomies are the result of nondisjunction in maternal meiosis, particularly meiosis I. This trisomy is the result of an error in meiosis II.
What is Trisomy 18?
This condition is often the result of dispermy and is associated with partial hydatidiform mole and persistent trophoblastic disease.
What is polyploidy (triploidy, tetraploidy, etc)?
This is the only genetic test that can identify the presence of a balanced translocation.
What is G-band karyotyping?
These measurements for crown rump length and mean gestational sac diameter are diagnostic for early pregnancy failure.
What are 7mm and 25mm?
This medication improves fertility rates in patients affected by hyperprolactinemia.
What is bromocriptine?
This trisomy is caused by errors in paternal meiosis.
What is trisomy 2?
This method of nutrition is employed by the embryo in early gestation prior to exposure to the maternal arterial circulation.
What is histotrophic nutrition?
Local nutrition supplied by neighboring endometrial glands, the main source of nutrition in the low O2 environment prior to expansion of the maternal arterial circulation.