Pathophysiology
Immunologic
Neoplastic/Endocrine
Cardiovascular/GI
Neuromuscular/Hemo
100
Which causative factor comes from diseases or conditions associated w/ chromosomal determinate or alterations
Genetic
100
Inflammatory reaction to strep infection, not infection itself
Rheumatic fever
100
Abnormal and uncontrolled growth of body cells
Cancer
100
Deposits on walls of coronary arteries, reduces blood flow to heart, major factor in heart attacks and strokes
CAD - Coronary artery disease
100
Demyelination of nerves of CNS, results in poor nerve transmission
MS - Multiple sclerosis 
200
Requires only one mutated gene to be affected, affected person has one affected parent. 50% chance that child will inherit mutated gene. 


Ex - Huntington's disease, neurofibromatosis, marfan syndrome.

Autosomal dominant
200
Type of immunity caused by exposure to antigen of other human origin
Isoimmunity
200
Malignant neoplasm of blood forming organism, abnormally high number of leukocytes produced
Leukemia
200
Inflammation of gall bladder, results from blockage by gallstones
Cholecystitis 
200
Hereditary condition which develops later in life, 50% of children will contract in 1 parent has condition. Characterized by uncontrolled jerking and writhing movements, may develop memory loss, personality and behavioral deterioration
Huntington's disease
300
Mutation X choromosome, males more frequently affected. 


Ex - Hemophillia A, Duchenne muscular dystrophy, male pattern baldness and red / green colored blindness

X linked recessive
300
Hyperactive immune response in the airway
Asthma 
300
Describe metastatic cascade
Development of primary tumor

Metastatic clone evolves

Proliferation of clone, invasion of vessel

Transport by circulation

Embolization

Invasion into surrounding tissue

Formation of new tumor

300
Delay between depolarization and re polarization of ventricles
Long QT syndrome
300
Increased destruction of RBC, related to antigen - antibody reaction. Causes include immune dysfunction, chemical / drug toxicity, bacterial infection
Hemolytic anemia
400
Also known as maternal inheritance


Ex - Leber's hereditary optic neuropathy

Mitochondrial
400
Chronic inflammatory autoimmune disease, unusual antibodies in blood target body tissues
Lupus
400
Accelerated atherosclerotic process, leading cause pf blindness, heart disease, kidney failure, premature death
Diabetes mellitus
400
General disease of the heart muscle, most often infectious cause
Cardiomyopathy 
400
Failure of bone marrow to produce blood components, due to injury or destruction on blood forming area of bone
Aplastic anemia
500
Caused by mutations on __ chromosome. Every son of an affected father, female offspring never affected. ___ chromosome is small, contains very few genes. 


Ex - infertility, hypertrichosis pinnae

Y linked
500
Can lupus be caused by immunizations? 
NO
500
Decreased insulin production or body not utilizing insulin
Type 2 diabetes mellitus 
500
Bulging or ballooning of left atrio-ventricular valve, cause regurgitation into left atrium
Mitral valve prolapse
500
Genetic disorder caused by a histocompatability complex dysfunction, marked by excessive absorption / accumulation of iron


How is this treated

Hemochromatosis


Phlebotomy - leeches

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