SUDs
The percent of alcoholism explained by genetics (on average).
Between 0.5 and 0.64 (Deak et al. 2021)
What is the first type of study used to investigate genetic influences?
Twin studies.
An inhibitory receptor subtype that alcohol binds to.
GABAA
The five SUDs examined by Deak et al. (2021).
Alcohol, nicotine, opioid, cocaine, cannabis.
What we call genes that are accidentally implicated with disease in genetic studies.
Neutral genes.
What happens to VTA DA neuron firing with alcohol.
Enhanced!
What disorder (in Deak et al.'s paper) had the largest range for estimates of genetic influence?
Nicotine use disorder (.3 to .7).
3 Types of studies used to look at genetic susceptibility in humans.
GWAS, linkage studies, candidate gene studies
Alcohol dehydrogenase and acetaldehyde dehydrogenase.
Approximately what percent of people have diagnosable alcohol use disorder at some point during their lives.
Up to 29.1% according to Deak et al (2021).
The p value that we want for genetic studies.
10^-8
A word that describes drugs that cause birth defects.
Teratogen.