Therapy
Which of the following forms of psychotherapy is most likely to describe a therapeutic goal as "improving ego functioning and self-esteem"?
(A)FAMILY THERAPY
(B)EXPOSURE THERAPY
(C) SUPPORTIVE PSYCHOTHERAPY
(D) DIALECTICAL BEHAVIOR THERAPY
(E) INTERPERSONAL PSYCHOTHERAPY
(C) SUPPORTIVE PSYCHOTHERAPY
WHICH OF THE FOLLOWING IDENTIFIES THE GENETIC DISTANCE BETWEEN LOCI IN POPULATIONS RATHER THAN IN FAMILIES?
(A) PEDIGREE ANALYSIS
(B) HAPLOTYPE ANALYSIS
(C) ASSOCIATION STUDIES
(D) LINKAGE DISEQUILIBRIUM
(E) RANDOM RECOMBINATION
(D) LINKAGE DISEQUILIBRIUM
Emil Kraepelin is credited with being the first to separate senile dementia from dementia praecox, which has since become known as:
(A) Delirium
(B) Schizophrenia
(C) Lewy body dementia
(D) Major depressive disorder
(E) Alzheimer's Disease
(B) Schizophrenia
WHICH ONE OF THE FOLLOWING IS THE MOST EFFECTIVE TREATMENT STRATEGY FOR PRADER-WILLI SYNDROME?
(A) APPETITE SUPPRESSANTS
(B) SSRIs
(C) STRICT DIETARY CONTROL
(D) WEIGHT LOSS SURGERY
(C) STRICT DIETARY CONTROL
WHICH POTENTIALLY FATAL CONDITION CAN BE CAUSED BY MUTATIONS IN THE BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX?
(A) PKU
(B) GAUCHER DISEASE
(C) TAY-SACHS DISEASE
(D) MAPLE SYRUP URINE DISEASE
(E) X-LINKED ADRENOLEUKODYSTROPHY
(D) MAPLE SYRUP URINE DISEASE
Which of the following interventions has been shown to improve medication compliance, social functioning, and overall reduction in psychiatric symptom relapse in patients with schizophrenia?
(A) MAJOR ROLE THERAPY
(B) MINDFULNESS TRAINING
(C) COGNITIVE REMEDIATION
(D) MOTIVATIONAL INTERVIEWING
(E) PSYCHOANALYTIC TREATMENTA
(C) COGNITIVE REMEDIATION
WHICH TYPE OF GENETIC VARIATION IS MOST INVESTIGATED IN GENOME-WIDE ASSOCIATION STUDIES?
(A) mRNA ABUNDANCE
(B) TRANSLATION EFFICIENCY
(C) INSERTIONS OR DELETIONS
(D) COPY NUMBER VARIANTS
(E) SINGLE NUCLEOTIDE POLYMORPHISMS
(E) SINGLE NUCLEOTIDE POLYMORPHISMS
When asked "How are you feeling today?" during an initial outpatient evaluation visit, the patient responds, "I am away. At the bay. Hey, Hey. What a day." What thought process is the patient exhibiting?
(A) Derailment
(B) Tangentiality
(C) Perseveration
(D) Clanging
(E) Flight of ideas
(D) Clanging
WHICH OF THE FOLLOWING TESTS IDENTIFIES GENOMIC DNA REGIONS THAT INTERACT WITH SPECIFIC PROTEINS OF INTEREST?
(A) RNA SEQUENCING
(B) EXON ARRAYS
(C) METHYLATION ARRAYS
(D) WHOLE-GENOME BISULFITE SEQUENCING
(E) CHROMATIN IMMUNOPRECIPITATION-SEQUENCING
(E) CHROMATIN IMMUNOPRECIPITATION-SEQUENCING
A 17 YO PRESENTS TO THE CLINIC WITH HIS PARENT DUE TO A CHANGE IN SLEEP HABITS. THE PARENT REPORTS THAT THE TEEN HAS BEEN SLEEPING ALL DAY AND NIGHT FOR THE LAST TWO WEEKS. HE HAS BEEN FALLING ASLEEP WHILE IN SCHOOL, AND HIS GRADES ARE BEGINNING TO DROP. THE PARENT ALSO STATES THAT WHEN THE TEEN IS AWAKE, HE IS IRRITABLE AND USUALLY CONSUMES EXCESSIVE AMOUNTS OF FOOD BEFORE RETURNING TO BED. THE PARENT REPORTS SIMILAR BEHAVIOR OCCURRING FOUR MONTHS AGO, BUT THE PATIENT HAD NORMAL SLEEPING HABITS DURING THE INTERIM. THE PATIENT DENIES LOW MOOD, AND STATES "I'M JUST SO TIRED, I FEEL LIKE I JUST CAN'T SLEEP ENOUGH." HE DENIES RECENT HEAD TRAUMA, ABRUPT LOSS OF CONSCIOUSNESS, OR EVENTS OF SUDDEN WEAKNESS. PHYSICAL EXAM IS GROSSLY NORMAL. WHICH OF THE FOLLOWING CONDITIONS IS THE MOST LIKELY DIAGNOSIS?
(A) NARCOLEPSY
(B) SUBSTANCE ABUSE
(C) KLEINE-LEVIN SYNDROME
(D) MAJOR DEPRESSIVE DISORDER
(E) CIRCADIAN RHYTHM DISORDER
(C) KLEINE-LEVIN SYNDROME
Which of the following is the best evidence-based treatment for somatic symptom disorder?
(A) Antipsychotic medication
(B) Supportive psychotherapy
(C) Cognitive behavioral therapy
(D) Selective serotonin reuptake inhibitor
(E) Annual visits to the primary care doctor
(C) Cognitive behavioral therapy
WHAT IS THE MOST COMMON FORM OF SEQUENCE VARIATION IN THE GENOME?
(A) SIMPLE TANDEM REPEATS
(B) COPY NUMBER VARIATIONS
(C) DELETION POLYMORPHISMS
(D) SINGLE NUCLEOTIDE POLYMORPHISMS
(E) SIMPLE SEQUENCE LENGTH POLYMORPHISMS
(D) SINGLE NUCLEOTIDE POLYMORPHISMS
The risk of tardive dyskinesia depends partly on the blood concentration of which of the following?
(A) OXYTOCIN
(B) TESTOSTERONE
(C) ESTROGEN
(D) PROGESTERONE
(E) GROWTH HORMONE
(C) ESTROGEN
WHICH OF THE FOLLOWING DISORDERS ARISES FROM A DEFECT IN THE MITOCHONDRIAL GENOME?
(A) RETT SYNDROME
(B) PKU
(C) FRIEDREICH ATAXIA
(D) HUNTINGTON'S CHOREA
(E) LYSOSOMAL STORAGE DISEASES
(C) FRIEDREICH ATAXIA
WHICH OF THE FOLLOWING GENETIC SYNDROMES IS THE MOST COMMON CAUSE OF INHERITED INTELLECTUAL DISABILITIES?
(A) RETT
(B) DOWN
(C) FRAGILE X
(D) PRADER-WILLI
(E) VELOCARDIOFACIAL
(C) FRAGILE X
A patient with comorbid addictive illness and social anxiety disorder discusses with a psychiatrist the painful experience of anxiety when attending the first Alcoholics Anonymous meeting. Which of the following statements by the psychiatrist would be consistent with twelve-step facilitation therapy?
(A)"Do you feel like drinking when you get so anxious?"
(B) "What thoughts do you have when you imagine entering a group of strangers?"
(C) "How did you master your social fears when you went to church last Sunday?"
(D) "You did the most important thing, you went to the meeting. It will get easier."
(E) "Maybe meetings are too anxiety provoking at this stage. Let's work on mindfulness."
(D) "You did the most important thing, you went to the meeting. It will get easier."
THE TEST USED TO PROBE FOR CYTOCHROME P450 POLYMORPHISMS USES WHICH TECHNOLOGY TO IDENTIFY GENETIC VARIANTS?
(A) KARYOTYPE ANALYSIS
(B) IN SITU HYBRIDIZATION
(C) MASS SPECTROSCOPY
(D) IMMUNOHISTOCHEMISTRY
(E) PCR
(E) PCR
A MICRODELETION AT 22q11.2 IS THE MOST COMMON GENETIC ABNORMALITY ASSOCIATED WITH WHICH OF THE FOLLOWING?
(A) AUTISM
(B) DEMENTIA
(C) PSYCHOSIS
(D) DEPRESSION
(E) LEARNING DISORDERS
(C) PSYCHOSIS
IN ADDITION TO CHROMOSOME 21, WHAT OTHER CHROMOSOME IS MOST COMMONLY INVOLVED IN TRUE ROBERTSONIA TRANSLOCATION RESULTING IN DOWN SYNDROME?
(A) 9
(B) 14
(C) 15
(D) 18
(E) 19
(B) 14
A PATIENT PRESENTS W/ A Hx OF FAILURE TO THRIVE IN INFANCY, HYPERPHAGIA, EARLY OBESITY, HYPOGONADISM, AND OCD. THE PT IS NOTED TO HAVE SHORT STATURE WITH SMALL HANDS AND FEET. THIS PT MOST LIKELY HAS WHICH OF THE FOLLOWING?
(A) DOWN
(B) WILLIAMS
(C) FRAGILE X
(D) ANGELMAN
(E) PRADER-WILLI
(E) PRADER-WILLI
According to psychodynamic theory, which of the following defense mechanisms are classified as mature? (Select three)
(A) Denial
(B) Humor
(C) Sublimation
(D) Suppression
(E) Displacement
(F)Rationalization
(G) Intellectualization
(H) Reaction Formation
(B) Humor
(C) Sublimation
(D) Suppression
POLYCOMB CHROMATIN STRUCTURES, WHICH ARE IMPORTANT FOR CELL DIFFERENTIATION, PLURIPOTENCY OF EMBRYONIC STEM CELLS, AND X-INACTIVATION, ARE CREATED THROUGH WHICH EPIGENETIC PROCESS?
(A) DNA METHYLATION
(B) HISTONE ACETYLATION
(C) HISTONE METHYLATION
(D) HISTONE PHOSPHORYLATION
(E) ATP-DEPENDENT CHROMATIN REMODELING
(C) HISTONE METHYLATION
Which of the following neuropeptide neurotransmitters has been most implicated in the pathogenesis of schizophrenia spectrum disorders?
(A) APELIN
(B) OXYTOCIN
(C) PROLACTIN
(D) CALCITONIN
(E) NEUROTENSIN
(E) NEUROTENSIN
WHICH OF THE FOLLOWING TYPES OF GENETIC STUDIES IS MOST SUITED TO DETECTING RARE VARIANTS OF LARGE EFFECT?
(A) LINKAGE DISEQUILIBRIUM
(B) PEDIGREE LINKAGE ANALYSIS
(C) AFFECTED SIB PAIR LINKAGE ANALYSIS
(D) FAMILY-TRIO GENOME-WIDE ASSOCIATION
(E) CASE CONTROL GENOME-WIDE ASSOCIATION
(B) PEDIGREE LINKAGE ANALYSIS
WHICH OF THE FOLLOWING IS MOST CLOSELY ASSOCIATED WITH SEVERE SELF-INJURY, PULLING ONE'S OWN FINGERNAILS, SELF-HUGGING, SLEEP PROBLEMS, EXCESSIVE NOSE PICKING, AND INSERTING OBJECTS INTO BODY ORIFICES?
(A) CORNELIA DE LANGE SYNDROME
(B) CRI-DU-CHAT SYNDROME
(C) LESCH-NYHAN SYNDROME
(D) SMITH-MAGENIS SYNDROME
(D) SMITH-MAGENIS SYNDROME