PHARMACOGENOMICS OF ANTIDEPRESSANTS
Which two cytochrome P450 genes primarily metabolize SSRIs and TCAs?
CYP2D6 and CYP2C19.
What is a SNP?
A single nucleotide polymorphism, a one-base variant.
DNA is found in the nucleus. True or False?
True.
The study of all the DNA in an organism.
Genomics.
What is my favorite color
Red/ Pink
A patient with **CYP2D6 4/4 is predicted to be what metabolizer phenotype?
Poor Metabolizer (PM).
What does “WGS” stand for?
Whole Genome Sequencing.
Your DNA changes every few days. True or False?
False — your DNA is stable; expression changes.
The study of all RNA molecules expressed in a cell.
Transcriptomics.
What are the main colors of my slides? (any 2 of the 4)
Black, Purple, Blue, White
Which allele is most common in East Asian populations and leads to reduced CYP2D6 activity?
*CYP2D6 10.
Which central dogma step turns DNA → RNA?
Transcription.
Mitochondrial DNA comes from which parent?
Mother.
The study of all proteins in a cell, tissue, or organism.
Proteomics.
Up Dog
What's Up Dog?
What effect does *CYP2C19 17 have on enzyme activity?
It increases transcription, resulting in rapid or ultrarapid metabolism.
What type of mutation changes an amino acid and may affect protein function?
A missense mutation.
Is all DNA coding?
No — most is non-coding regulatory or structural.
The study of chemical modifications to DNA that don’t change the sequence.
Epigenomics.
What is my full name
Avya Pandhi
Explain how population allele frequency differences impact antidepressant dosing recommendations.
Populations differ in functional allele frequencies (e.g., *10 in EAS, *4 in EUR), leading to different proportions of PM/IM/NM/UM phenotypes. These differences require dose adjustments or alternate antidepressant selection to avoid toxicity or treatment failure.
What is the purpose of a reference genome?
To serve as a standard sequence for alignment, variation calling, and comparative genomics.
Can identical twins have different gene expression patterns?
Yes, due to epigenetics and environment.
The study of metabolites and chemical products left behind by cellular processes.
Metabolomics.
What was the last word on my slides?