Gout
This disease develops when serum uric acid levels are ≥ 6.8 mg/dL
What is gout?
The type of physician who manages a patient with uncontrolled gout
Who are rheumatologists?
These agents inhibit purine metabolism which affects uric acid production
What are xanthine oxidase inhibitors?
Anaphylaxis and infusion reactions, glucose-6-phosphate dehydrogenase deficiency associated hemolysis, and methemoglobinemia are listed under this safety section for pegloticase
What is the boxed warning for pegloticase?
These foods — including meat, seafood, alcohol, fatty foods, and fructose — can increase gout risk
What are purine-rich foods? or what foods are high in purine?
The treatment goal for serum uric acid in gout is below this level
What is 6 mg/dL?
This oral urate lowering therapy is generally recommended as first-line therapy by American College of Rheumatology guidelines
What is allopurinol?
This medication is given with pegloticase to potentially reduce the development of anti-drug antibodies
What is methotrexate?
This waste product is formed when the body breaks down purines
What is uric acid?
Lowering alcohol, reducing purines and fructose, losing weight, and exercising
What are lifestyle considerations for managing gout?
This uricosuric is a second-line uric acid lowering therapy
What is probenecid?
Pegloticase is administered this way and at this frequency
What is by intravenous (IV) infusion every two weeks?
The accumulation of monosodium urate (MSU) crystals in joints and soft tissues — causes pain and inflammation
What is tophus? Or what are tophi?
NSAIDs, colchicine, and glucocorticoids are recommended for this purpose in gout
What are first-line treatments for acute gout flares?
This agent non-competitively blocks the active site for xanthine oxidase
What is febuxostat?
Pegloticase lowers serum uric acid by catalyzing this reaction
What is the oxidation of uric acid to allantoin?