Annovera Knowledge
The estrogen exposure of Annovera is approximately equivalent to this daily microgram dose of ethinyl estradiol.
What is about 13 mcg EE per day?
Bijuva is the only FDA-approved oral capsule that combines these two hormones for menopausal symptom treatment.
What are estradiol and progesterone?
he estrogen dose in each active Nextstellis tablet is this amount of estetrol.
What is 14.2 mg of estetrol?
Roughly this percentage of women in the US use tampons during their menstrual cycle.
What is about 70 to 75%?
This is the tab where you can find a specific providers prescribing history over time, your sample history, and card claim details.
What is the Prescriber Search tab?
Annovera releases approximately this daily dose of segesterone acetate.
What is about 150 micrograms per day?
Unlike synthetic progestins used in many HT products, Bijuva contains this naturally occurring form of progesterone.
What is micronized progesterone?
PK data in the PI show that estetrol reaches steady-state plasma concentrations after approximately this many days of continuous dosing.
What is about 5 days?
Each year in the US, about this many unintended pregnancies occur among women using birth control pills (often due to missed doses).
What is approximately 500,000+ unintended pregnancies?
This is the tab where you can view Rx trends over time for a specific provider or your territory as a whole.
What is the Writing Trends tab?
Annovera’s clinical trials excluded women above this BMI after early thromboembolic events were observed in this population.
What is BMI ≥ 29 kg/m²?
The inclusion of progesterone in Bijuva allows estrogen therapy in women with a uterus by reducing the risk of this estrogen-driven condition.
What is endometrial hyperplasia (or endometrial cancer)?
According to the PI, estetrol exhibits lower binding affinity for hepatic estrogen receptors compared to ethinyl estradiol, contributing to reduced effects on this group of proteins involved in clotting.
What are liver-synthesized coagulation factors (hemostatic proteins)?
Typical-use adherence for oral contraceptive pills is around this percentage (not perfect use).
What is about 91% effective (or ~9% failure rate annually)?
This is the area in PowerBI where you can identify zip codes where there is business opportunity not being captured.
What is the Targeting tab?
In pharmacokinetic studies, steady-state hormone levels with Annovera were achieved after approximately this many days of continuous use.
What is about 7 days?
Clinical trial data in the PI demonstrated that Bijuva significantly improved both the frequency and severity of vasomotor symptoms within this general timeframe.
What is within the first several weeks of treatment (around 4–12 weeks)?
Pharmacokinetic data in the PI show that the mean half-life of drospirenone in Nextstellis is approximately this many hours, supporting once-daily dosing.
What is about 30 hours?
About this percentage of menopausal women experience moderate to severe hot flashes.
What is roughly 75 to 80%?
This is the tab you would use to see how the market is growing/declining over time overall and for each product.
What is the Marketshare tab?
When comparing mean serum concentrations of ethinyl estradiol between Cycle 1 and Cycle 13, the PI demonstrates this key pharmacokinetic finding.
What is consistent hormone exposure with minimal change across cycles?
In the pivotal clinical trials described in the PI, women treated with Bijuva experienced an average reduction of approximately this many moderate to severe hot flashes per day at Week 12 compared to baseline.
What is about 6 to 7 fewer hot flashes per day?
According to pharmacokinetic data in the PI, the mean terminal half-life of estetrol after repeated dosing in Nextstellis is approximately this many hours.
What is about 28 hours?
Studies show that up to this percentage of women discontinue hormone therapy within the first year due to concerns, side effects, or misinformation.
What is around 50%?
This is the tab in PowerBI where you can see provider volume each week that contributed to your IC.
What is the Units Trend tab?