Trial By Design
Presented in tandem at SGO 2023, these trials established immunotherapy as a new standard of care for advanced or recurrent endometrial cancer
If an itis develops while on pembrolizumab, these agents are considered the gold standard to control a raging immune system
Steroids
Although it offers no therapeutic benefit to clear active infections or treat existing cervical dysplasia, CDC guidelines still recommend administering this to eligible patients with an abnormal Pap or positive high-risk HPV result to protect against other strains they have not yet acquired
What is a gardasil vaccine
This term refers to the separation of a surgical incision's outer edges, a potential post-operative complication following gynecologic oncology procedures like a radical hysterectomy.
What is wound dehiscence
After a prolonged period of negative trials using immunotherapy in ovarian cancer, this trial established what new regimen for platinum resistant ovarian cancer? (Trial name and regimen please)
Keynote B96 - paclitaxel with pembrolizumab +/- bevacizumab
Pneumonitis
Following surgical menopause, chemotherapy-induced ovarian failure, or endocrine therapy, many gynecologic cancer survivors experience this common genitourinary syndrome characterized by vaginal dryness, irritation, dyspareunia, and recurrent urinary symptoms.
What is vaginal atrophy
Post-operative fever, localized tenderness, and persistent leukocytosis following an open total abdominal hysterectomy with bilateral salpingo-oophorectomy may indicate the formation of this localized collection of pus.
What is a pelvic (or abdominal abscess)
Avutometinib and defactinib combination therapy for low-grade serous ovarian cancer is FDA approved in the presence of these mutations
KRAS mutations
I didn't know trametinib would make me feel like a teenager again - what can you give me to manage my breakouts?!
Topical clindamycin with oral doxycycline
Often performed for malignant bowel obstruction or severe ascites in advanced ovarian cancer, this bedside or interventional radiology procedure uses a small tube to drain fluid or decompress the stomach for symptomatic relief without curative intent.
What is a venting gastrostomy
Dysuria, flank discomfort, and a low-grade post-operative fever following a laparoscopic hysterectomy often point to this common bacterial infection
What is a urinary tract infection/cystitis
This trial combines a glucocoticoid receptor antagonist in combination with a special taxane, so avoid all steroid use please
ROSELLA - relacorilant with nab-paclitaxel
Alopecia is reported at 20-30% in trials use this class of targeted therapeutic agents?
Anti-body drug conjugates (ADCs)
To prevent radiation-induced vaginal stenosis and shortening following pelvic radiotherapy or brachytherapy, clinicians routinely prescribe this progressive set of tube-shaped medical devices to maintain tissue elasticity and vaginal caliber.
What are vaginal dilators
Hemoperitoneum, tachycardia, and a drop in hemoglobin following a TAH-BSO with pelvic and para-aortic lymph node dissection for endometrial carcinoma are hallmark signs of this acute vascular complication, often requiring surgical re-exploration.
What is post-operative hemorrhage (or bleeding)
Speaking of low grade ovarian cancer, this trial recently showcased that chemotherapy followed by letrozole maintenance should be standard of care, unless you have no gross residual after surgery
You're old so your eye sight isn't great - but let me add these therapies to make sure we tip that vision right over the edge. (name at least 2 of us)
Mirvetuximab, tisotumab, trametinib, avutometinib/defactinib
Approved by the FDA as the first neurokinin 3 (NK3) receptor antagonist for non-hormonal management, this oral medication targets temperature-regulating neurons in the hypothalamus to reduce moderate-to-severe hot flashes.
What is veozah or fezolinetant
Post-operative tissue necrosis or accidental intra-operative trauma during a radical vulvectomy can create this abnormal epithelialized tract between the bladder and the vaginal vault, leading to continuous, uninhibited urinary leakage.
What is a vesicovaginal fistula