People
Who wrote Your Inner Fish?
Neil Shubin
Name 2 reasons why chicken eggs were used in initial embryonic limb research.
What animal was studied in the experiment?
mice
What is the title of the chapter covered?
Handy Genes
Who was the awesome woman who worked under John Saunders and discovered the duplication of digits in chicken eggs?
Mary Gasseling
What does ZPA stand for?
Zone of Polarizing Activity
Which bone was mainly studied in the experiment?
sphenoid bone
Where does the pituitary gland sit in the sphenoid bone?
Sella Turcica
Who performed the sonic hedgehog experiments on sharks and skates?
Randy Dahn
What happened when Dennis Summerbell placed foil over the ZPA in chicken embryos?
Digits did not develop past the foil
Why did researchers experiment with heterozygous SHH mice?
because they previously were considered phenotypically unremarkable
What is the chorioallantoic membrane? Why is it significant?
vascular membrane in eggs that surrounds the embryo
it is where limb buds were placed after being transplanted
What were the names of the two men who discovered patches tissue that are in control of skeleton formation within limbs?
First and last names of BOTH!
Edgar Zwilling and John Saunders
True or False: The sonic hedgehog gene turned on at the same time in skates as it did in chickens.
True
Name 1 craniofacial developmental abnormality found in the mutant mice in the experiment?
more pronounced curvature of the head, skull was shorter, parietal bone length was reduced, Interparietal, nasal and basioccipital bones were significantly narrow in mutant mice, Length between coronoid and angular processes was significantly smaller in mutants
What animal was the sonic hedgehog gene named for?
Chickens
What insect did did Cliff Tabin study?
Flies