HCM
What is the most common clinical sign of HCM?
Tachypnea/dyspnea
What is the most common signalment of a cat with ATE?
Maine Coons and Ragdolls have a known mutation in what gene that predisposes to HCM?
MyBPC3
What is the gold standard method of diagnosing HCM?
Echocardiogram
What is the primary drug for control of pulmonary edema and effusions in cats with CHF?
Furosemide
What are the three most negative prognostic indicators for cats with HCM?
CHF, ATE, and hypothermia
For hospitalized ATE patients, the most important treatments in the first 24 hours are anticoagulants and __________
Analgesics
What are two iatrogenic interventions that could precipitate CHF in a cat with HCM?
General anesthesia, fluid therapy
What biomarker can be used to distinguish severe HCM from subclinical or early HCM?
NT-proBNP
The primary treatment goals in HCM are to treat and/or prevent what two major consequences of a dilated LA?
CHF and ATE
What primary functional abnormality caused by LV thickening results in adverse clinical signs in HCM?
Diastolic dysfunction
What are the three most positive prognostic indicators for cats with ATE?
No CHF, normothermia, only one limb involved
What drug currently in human clinical trials improved diastolic function in HCM research cats?
Mavacamtem
What are two imaging modalities used in human medicine that could also be used to definitively diagnose HCM in cats?
CT and MRI
What intervention should be taken when a cat has severe pleural effusion and dyspnea?
Thoracocentesis
What is the most common cause of a heart murmur in HCM?
What are the two most common sequelae to ATE in cats that are treated and survive?
Reperfusion injury, AKI
HCM murmurs are typically dynamic (louder with stress); changes in what component of cardiac output causes it to be dynamic?
Contractility
What is the "5 P Rule" for diagnosing ATE?
Purple/cyanotic/pale toes, polar/poikilothermy, pulselessness, paralysis/paresis, pain
What is the gold standard drug for preventing and treating ATE (both first-time and recurrent)?
Clopidogrel +/- rivaroxaban