Acronyms
Pathophysiology
Current Therapies
Telapravir
Clinical Endpoints
100
HCV
What is Hepatitis C Virus
100
The percentage of patients with acute infection who develop chronic HCV.
What is 60-85%
100
The majority of HCV patients are diagnosed by this type of doctor.
What is the General Pratictioner (GP)?
100
Telapravir is indicated only in this genotype.
What is genotype 1?
100
The absence in serum of detectable HCV RNA by PCR assay 24 weeks after treatment stop (all genotypes).
What is Sustained Virological Response (SVR)?
200
DAA
What is Direct Acting Antiviral
200
The percentage of patients chronically infected who go on to develop liver cirrhosis.
What is 5-25%
200
GPs typically refer HCV patients to these physician types.
What is the gastroenterologist and hepatologist?
200
Telapravir must be used with these per the product label.
What are peg-IFN and ribavirin?
200
Undectable serum RNA levels at treatment week 4.
What is Early Virologic Response (EVR)?
300
RBV
What is Ribavirin
300
I am the cell target for the Hepatitis C virus.
What is the hepatocyte?
300
This is the primary goal of HCV treatment.
What is elimination of the HCV virus?
300
These are potentially life-threatening side effects seen in the drug.
What are rash and anaemia?
300
Tissue scarring or accumulation of collagen that ultimately destroys liver architecture.
What is fibrosis?
400
RdRp
What is RNA dependent RNA polymerase
400
Protease Inhibitors block splicing of the HCV polypeptide and prevent this process from occurring.
What is translation (and post-translation processing) of the RNA?
400
This is the number of current drug classes used to treat HCV.
What is 5? Bonus: Inteferons, Protease Inhibitors, Ribavirin, Ursodeoxycholic acid (UDCA), glycyrrhizic acid
400
% of patients acheiving SVR in the treatment-naive population in phIII trials.
What is 80%?
400
A consequence of chronic liver disease where liver tissue is replaced with scar tissue and regenerative nodules.
What is cirrhosis?
500
I am the acronym for Pegasys
What is peg-IFN-a (alfa)-2a
500
The HCV genome encodes a polyprotein of approximately this many amino acids.
What is 3000 amino acids?
500
These are the names of the two manufacturers of marketed interferons (alpha-2a and alpha-2b).
What are Roche (Pegasys) and Merck (PegIntron)?
500
31%, 57% and 84%
What are the SVR rates for non-responders (nulls, partials and relapsers respectively)?
500
Normalization of serum ALT levels (between 5 IU/L and 60 IU/L) is an indication of this.
What is a reduction in liver inflammation?
M
e
n
u