History
Genetic
Diagnosis
Treatment
What's on the Horizon
100
The symptoms of Huntington's Disease were first described in 2001
a. True
b. False
They were described by George Huntington in 1872
100
Only men can inherit Huntington's disease.
a. True
b. False
b. False
Both men and women can be born with the mutant HD gene.
100
The diagnostic test of choice to determine if one has the HD mutation
Hint:
a. Brain biopsy
b. Direct Genetic test for HD
b. What is the Direct genetic test for HD?
100
There are no medications available to treat the symptoms of HD
a. True
b. False
b. False
Currently, it is possible to treat symptoms of HD. There are absolutely effective medications (and nonpharmacologic strategies) available to treat HD.
100
Clinical trials are dangerous because they use new practices and medicines.
a. True
b. False
b. False
Clinical trials are designed for research purposes, and as a result, some level of risk is involved. However, investigational drugs are given to clinical trial participants only after the drugs have gone through a rigorous testing process and scientific evidence indicates that the drug is likely to be effective and safe for use in humans.
200
Which of the following day is designated as International Huntington’s Disease Awareness Day?
a. August 15th
b. May 15th
May 15th is International Huntington’s Disease awareness day. The triad of symptoms seen in HD includes motor symptoms (abnormal movements), neuropsychiatric symptoms (mood issues) and cognitive symptoms (memory issues). The impact of HD is not on the patient alone, but their entire families and it is important to raise awareness about this debilitating disorder.
200
If you have the gene you will start showing symptoms at the same age as your parents
a. True
b. False
b.False
200
HD only affects adults
a. True
b. False
b. False
< 10% Juvenile Huntington disease
200
A movement expert who helps patients by prescribed exercises
a. Chiropractor
b. Physical therapist
Who is a Physical therapist?
200
mRNA-based COVID vaccines are safe for patients with HD
a. True
b. False
a. True
300
The HDSA (Huntington's Disease Society of America) was founded by
a. Marjorie Guthrie
b. Bob Dylan
a. Who is Marjorie Guthrie
300
HD can skip generations
a. True
b. False
b. False
HD is an autosomal dominant inherited disorder, and because of this the disease does not skip generations.
300
Family members with HD will have the same symptoms
a. True
b. False
b.False
Everyone experiences HD differently
300
Abnormal movement (Chorea) in HD can get worse with stress and anxiety.
a. True
b. False
a. True
300
HD is caused by a single gene mutation and is therefore a good candidate for therapeutic gene product modification.
a. True
b. False
a. True
Unfortunately the ASO studies did not pan out and one sponsor (Roche) stopped dosing prematurely, the other (Wave) had a negative outcome.
Antisense oligonucleotides (ASOs) is a promising approach to gene silencing. ASOs are small single-stranded pieces of DNA that decrease the production of the mutant HD protein.
400
The oldest HD support organization
a. IHA (International Huntington Association)
b. HDSA (Huntington's Disease Society of America)
b. What is HDSA?
HDSA, founded in 1967
400
The number of CAG repeats will tell you which symptoms your will experience.
a. True
b. False
False, the number of CAG can only roughly approximate the age of onset of symptoms
400
All patients with HD will experience depression
a. True
b. False
b. False
Not all individuals will experience depression. If they do, however, there are effective medications and help.
800-273-8255
400
Exercise and lifestyle change can improve motor function and balance in HD
a. True
b. False
a. True
Physical therapy or exercise, especially aerobic exercise and resistance training
400
In gene therapy using AMT-130 (UniQure trial), the substance is directly delivered to:
a. Spine
b. Brain
c. Skin
b. Brain
AMT-130 consists of an AAV5 vector carrying an artificial micro-RNA specifically tailored to lower the mutant and wild type huntingtin protein level.
500
United States' collaboration with which country resulted in discovering the exact location of the HD gene
Hint: Options include
a. Spain
b. Mexico
C. Venezuela
C. What is Venezuela?
US-Venezuela Collaborative Research Project
500
The chance of inheriting HD from a parent
a. 25%
b. 50%
c. 75%
b. 50%
500
Typical motor symptom of HD
a. Tremor (a rhythmic movement in one or more parts of body)
b. Chorea (an involuntary movement, random, jerk like movements, derived from the word “to dance”)
b. Chorea
Tremor is less common in HD
500
Deutetrabenazine (AUSTEDO™) is approved by FDA to treat which symptom in HD
a. Irritability
b. Involuntary movements (chorea)
b. What are involuntary movements/What is chorea?
500
HD research can also contribute to the knowledge of other movement and cognitive disorders (e.g., Parkinson’s disease)
a. True
b. False
a. True
Movement disorders share common factors