Gurley et al., 2008
This pathway specifies posterior identity during regeneration and homeostasis.
What is Wnt/β-catenin?
This gene is required to establish A-P polarity during planarian regeneration.
What is Smed-βcatenin-1?
The model organism used in these two papers.
What is planaria?
Technique used to silence particular Wnt pathway components.
What is RNAi?
This phenotype was observed when knockdown animals were required to regenerate just the head tip.
What is regeneration of the head tip?
The type of animals that may have experienced losses in Wnt family genes over evolutionary time.
What is animals with simple body plans?
Pathway component that negatively regulates β-catenin via phosphorylation and destruction.
What is APC?
The two additional locations in which head-like tissue appeared in knockdown animals during homeostasis, besides in the posterior.
What is periphery and pharynx?
Mutations in this gene are linked to colon cancer.
What is APC?
Pathway component that is upstream to β-catenin - RNAi silencing reveals a phenotype that is similar to β-catenin RNAi.
What is Dishevelled?
These two anterior markers were used to identify heads during sagittal/lateral amputations.
What is PC2 and PDS?
Organism that applies Wnt/β-catenin signaling and has the ability to regenerate its heart, spinal cord, kidneys, fins, etc.
What is zebrafish?
The two anatomical systems with characteristic anterior and posterior features that were analyzed to confirm A/P identity.
What are the CNS and digestive systems?
VC-1 played this role in the experiment.
What is an antibody that specifically recognizes planarian photoreceptor neurons?
This syndrome is characterized by the loss of limb development caused by a mutation in the Wnt gene.
What is Tetra-Amelia syndrome?