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A 31-year-old woman presents to the ED complaining of a fever, headache, and blurry vision. She states that one week ago she developed a furuncle on her midface that she tried to “pop” by squeezing it. On examination, you note mild proptosis, periorbital edema, and chemosis of the right eye. Extraoculomotor testing reveals a lateral gaze palsy of the right eye. Vital signs are T 39.2°C, BP 128/88, P 105, RR 18. Which of the following is the most likely diagnosis?
What is cavernous sinus thrombosis. This is a life-threatening condition that is usually a late complication of an infection of the central face or paranasal sinuses. The complex network of facial veins with multiple anastomoses allows spread of infection from the face to the cavernous sinus. Staphylococcus aureus is the most common associated organism. Patients initially recall having a sinusitis or midface infection during the preceding five to ten days. Subsequently, the patient develops a headache, periorbital edema, and cranial nerve signs (related to structures within the cavernous sinus). Cranial nerve VI is most commonly affected, presenting as a lateral gaze palsy because it lies freely within the sinus. Periorbital edema may be the earliest finding and chemosis and proptosis results from occlusion of the ophthalmic veins. The diagnosis is clinical but is often aided by CT scan or MRI with IV contrast that reveals a filling defect within the cavernous sinus.