Anemias
MCV < 80
What is microcytic?
patients with this disease lack factor VIII
What is hemophilia A?
First line treatment for ITP
Glucocorticoids (prednisone or dexamethasone)
MC childhood malignancy
What is ALL?
spherocytes on smear
What is hereditary spherocytosis?
Sx: fatigue, tachycardia, smooth tongue, Pica, koilonychia
which diagnosis
What is iron deficiency anemia?
treatment for this disorder is factor IX infusion
What is Hemophilia B?
Pentad of: thrombocytopenia, anemia, fever, kidney disease, neurological findings
What is TTP?
MC leukemia in adults
What is CLL?
howell-jolly bodies and target cells
What is Sickle Cell Anemia?
Labs of increased methylmalonic acid, increased homocysteine, decreased cobalamin, MCV >100
most likely cause
What is B12 deficiency?
This is the most common inherited bleeding disorder
What is Von Willebrand Disease?
normal platelet range
What is 150,000 - 450,000/uL?
associated with Philadelphia chromosome, translocation between 9 and 22
What is CML?
Auer rods on smear
What is AML?
X linked disorder, MC enzyme deficiency, induced by: infections, fava beans, dapsone, bactrim, etc.
most likely disorder
What is G6PD Deficiency?
Green leafy vegetables could be helpful for patients with this deficiency
What is Vitamin K deficiency?
1. underproduction
2. non-immune mediated
3. immune mediated
these are causes of what?
What are three causes of thrombocytopenia?
lymph node biopsy shows reed sternberg cells confirms which diagnosis
What is Hodgkin Lymphoma?
smudge cells on smear
What os CLL?
MC first presentation = dactylitis
which disease
Sickle cell anemia
Clinical presentation of bleeding at multiple sites, purprua fulminant, trousseau syndrome
What is DIC (disseminated intravascular coagulation)?
etiology of congenital or acquired deficiency or ADAMTS-13
What is TTP?
Pathophysiology includes B cell symptoms, presentation of LAD, fever, night sweats, weight loss
What is Non-Hodgkin Lymphoma?
rouleaux formation on smear
What is Multiple Myeloma?