Blood and Bugs
Infectious agent causing of aplastic crisis in sickle cell anemia?
Parvovirus
Most frequent cause of normocytic anemia?
Inflammation
At what WBC level do symptoms of leukostasis appear?
Greater than 100x10^9/microL
Two direct oral anticoagulants approved as initial therapy without heparin for venous thromboembolism disease?
Apixaban and Rivaroxaban
Two most common sites of bleeding in hemophilia A?
Joints and muscles
Blood banking procedure to prevent primary alloimmunization to HLA antigens?
Leukocyte reduction
Target hemoglobin level for patients with sickle cell disease undergoing moderate-risk surgery?
10 g/dL
Leukemia most commonly associated with leukostasis syndrome?
AML or CML
All direct oral anticoagulants with generic name ending in 'xaban' have this common mechanism of action?
Xa inhibition
Meaning of Wet Purpura?
A: Hemorrhagic blisters in mucous membranes, such as oral mucosa
The leading cause of mortality associated with blood product administration
TRALI
Types of alpha thalassemia?
Silent carrier, Alpha thal, HgH, Barts
Two most common organ system dysfunctions associated with leukostasis syndrome?
A: Pulmonary (dyspnea, hypoxia) and CNS (confusion, ataxia, somnolence, coma)
Hydroxyurea therapy in sickle cell disease increases this hemoglobin type?
Hgb F
Medical term for changes in nails seen with Iron deficiency anemia?
Koilonycha (spoon nails)
Irradiated blood prevents this fatal transfusion-related complication
GVHD
Condition associated with elevated homocysteine and normal methylmalonic acid levels?
Folate deficiency
Most patients with leukostasis syndrome are also at risk for this emergency?
TLS
First drug to inhibit the action of the BCR-ABL fusion gene?
Imantinib
Most common cause associated with warfarin skin necrosis?
Protein C deficiency
Patients with hemochromatosis are at risk for this bacterial infection?
L. monocytogenes, Y. enterocolitica, V. vulnificus, Klebsiella sp (any one)
Two diagnoses most commonly accounting for acute fall in hemoglobin in patients with sickle cell anemia?
Aplastic crisis and hyperhemolytic crisis
Critical treatment for leukostasis?
Hematopoietic stem cell transplants and cytoreduction
Definitive treatment for porphyria cutanea tarda?
Phlebotomy
Cause of splenomegaly and hepatomegaly in myelofibrosis (myeloid metaplasia)?
Extramedullary hematopoeisis