Hematopoiesis
Organ that produces EPO
Kidneys
DNA fragments seen in RBCs with wright stain
Howell Jolly Bodies
High N:C ratio, fine euchromatin, and nucleoli
Blast cell
Poikilocyte associated with thalassemia(s)
Organ that produces most factors
Liver
First stage in the myeloid lineage where secondary(specific) granules are visible
Myelocyte
Döhle Bodies, large platelets, and low platelet counts are associated with this anomaly
May Hegglin Anomaly
Non-pathologic phenomena that causes hypo-segmentation in segmented neutrophils
Pegler-huet
Macrocytes and dacrocytes are associated with this disease
XII, XI, IX, VIII
Intrinsic pathway
Last RBC precursor with a nucleus
Orthochromatic normoblast/metarubricyte.
May be referred to as a "NRBC" on the bench.
Multiple dots on surface of RBC
Composition: denatured hemoglobin
Associated with g6pd deficiency
Heinz Bodies
Large myeloid cell with many azurophilic granules, commonly seen in CML
Promyelocyte
MCV <80, no central pallor
Spherocytes
Collagen, prekallikrein, & HMWK
Contact Group
Myelocyte
Inclusions seen in lead poisoning, alcohol abuse, and Myelodysplastic syndromes
Siderocytes/Sideroblasts
This cells granules contain heparin and histamine
basophil/mast cell
Abnormal Cells seen in SC disease
Hemoblobin C crystals and drepanocytes
Deficiency in factor VIII
Hemophilia A
Earliest recognizable RBC precursor
Pronormoblast (Rubriblast)
Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are all parasites that transmit what
Malaria
These peripheral cells are capable of phagocytosis
M:E ratio in hemolytic anemias
In hemolytic anemia, the M:E ratio (myeloid to erythroid ratio) is typically decreased due to an increased number of erythroid precursors in the bone marrow as it attempts to compensate for the destruction of red blood cells in the bloodstream