Heme Issues/Basics
Normal concentration of hemoglobin A in an adult
97%
MCV 80-100 fL
MCHC 32-37%
TIBC associated with IDA
Increased
Macrocytic anemia associated with neurological changes
Vitamin B12 deficiency
Major cause of Hereditary Spherocytosis
Defective spectrin
pH of Wright's stain
6.4
Congenital form of aplastic anemia
Fanconi's anemia
Microcytic anemia associated with increased cytokine production
Anemia of chronic disease (ACD)
Macrocytic category associated with impaired DNA synthesis
Megaloblastic
DAT result associated with PK deficiency
Negative
Angle used to make a wedge smear with a sample from a PV patient
Decreased
N/N associated with a "crowded bone marrow"
Myelophthisic anemia
Microcytic anemia associated with decreased protoporphyrin rings
Sideroblastic anemia
Name two megaloblastic changes associated with vitamin B12 deficiency (NOT macrocytes)
Giant bands
Giant metamyelocytes
Pancytopenia
G6PD deficiency
Indice and normal range associated with anisocytosis
RDW cv 11.0-14.5%
RDW SD 32-42 fL
EPO value associated with Anemia of Chronic Renal Disease (CKD)
Decreased
Serum iron decreased; Increased ferritin;
TIBC increased
Sideroblastic anemia
Part I: 6%
Part II: 17%
Interpretation
Pernicious anemia (defective, decreased IF)
Reticulocyte count, LD, Haptoglobin results associated with Hereditary Spherocytosis
Increased reticulocyte count
Increased LD
Decreased Haptoglobin
3 scenarios associated with dual population
1. Transfusion
2. IDA with treatment
3. Sideroblastic anemia
N/N associated with leukoerytoblastosis
Myelopthisic anemia
Hemoglobin population change associated with Thalassemia Minor
Slight increased A2
3 RBC morphologies associated with chronic liver disease
1. round macrocytes
2. acanthrocytes
3. target cells
Oxygen dissociation curve change associated with PK deficiency