Red Cell Riddles
What is hemolysis?
Acute neutrophilia, toxic granulation, and Dohle bodies are associated with this
What are bacterial infections?
This test is the most sensitive and specific for detecting iron-deficiency anemia
What is ferritin?
This type of anemia is characterized by lack of intrinsic factor (IF)
What is pernicious anemia?
This test would most likely be able to distinguish a leukemoid reaction from CML
What is LAP score?
This anomaly is morphologically similar to toxic granulation and is often seen in patients who have poor mucopolysaccharide degradation
What is Alder-Reilly?
This is the treatment of choice for thalassemias
What are supportive transfusions?
This treatment offers the best prognosis for aplastic anemia
Patients with sickle cell disease have an inherent resistance to this infection
What are plasmodium infections?
This disorder is characterized by a defect in glucocerebrosidase that results in a macrophage with cytoplasm that appears wrinkled or striated
What is Gaucher's disease?
This term describes anemia characterized by deficient iron for Hgb synthesis
What is sideropenic?
Hypersegmented neutrophils (PMNs) are commonly found in this type of anemia
What is megaloblastic anemia?
This is the screening test for infectious mononucleosis
What is the heterophile antibody test?
This infectious agent can be transmitted from mother to a growing fetus and can result in physically and mentally impaired development
What is Toxoplasma gondii?
This RBC morphology marks most types of thalassemia
What are target cells?
This poikilocyte would lead to a suspicion of myelopthisic anemia rather than a pure red cell aplasia
What is a dacryocyte?
This hemoglobinopathy has the highest prevalence worldwide
What is Hgb S?
This patient population is most affected by acute lymphoblastic leukemia
What are children?
This test measures the maximum amount of iron able to be bound to transferrin
What is TIBC?
This type of anemia is characterized by decreased erythropoiesis in the bone marrow
What is hypoproliferative anemia?
This is the reason that bleeding, infections, and anemia are common complications of chemotherapy
What is the drugs that are used kill normal cells as well as leukemic cells?
This myeloproliferative disorder typically produces a dramatic increase in all cell lines
What is PV?
This is another name for the phenotype of a-thalassemia major (--/--)
What is hydrops fetalis?
An increased osmotic fragility test is most likely to lead to a diagnosis of this inherited disease
What is hereditary spherocytosis?
a-thalassemia major results from the deletion of this many alleles of the alpha chain gene
What is 4?
The Philadelphia chromosome results from the fusion of these 2 chromosomes
What is chromosomes 9 and 22?
This is the storage form of iron
What is ferritin?
Infection with this virus can lead to aplastic anemia because it infects stem cells, eliciting an immune response to destroy the stem cells
What is EBV?
CML is typically diagnosed in this patient population
What is elderly male and female patients?
This characteristic poikilocyte is often seen in the PB of patients with PMF
What is a dacryocyte?
This test should always be done if a dx of thalassemia (or any hemoglobin problem) is suspected?
What is hemoglobin electrophoresis?
This is the screening test used to screen for PNH?
What is the sugar-water test?
This is the name for quantitative defects in globin chain synthesis
What are thalassemias?
This disease presents with extreme and consistent thrombocytosis with giant, bizarre platelet forms in the peripheral blood. Megakaryocytes and megakaryocyte fragments can be present. Abnormalities in plt aggregation and adhesion are common.
What is ET?
This type of anemia is characterized by a block in iron release from macrophages
What is anemia of chronic disease (ACD)?
What is erythopoietin?
This is the expected platelet count in any acute leukemia
What is decreased?
What are kappa and lambda?
This is the reason that it is so much easier to become folate-deficient than B12-deficient
What is the body has much larger stores of B12 than folate?
This is the principle confirmation test for HS
What is osmotic fragility?
This disease results when 3 of the 4 alpha genes are deleted
What is hemoglobin H disease?
A plasma cell is referred to as a fully differentiated type of this cell
What is a B cell?
This organ is the primary storage depot for iron
What is the liver?
This anemia is a rare congenital progressive erythrocyte aplasia (pure red cell aplasia) that is caused by an intrinsic defect of erythroid progenitor cells
What is Diamond-Blackfan?
This is another name used to describe plasma cell disorders (2 words)
What are monoclonal gammopathies?
This is the confirmation test for paroxysmal cold hemoglobinuria (PCH)
What is the Donath-Landsteiner test?
This test is the best indicator of folate status in the body over the past month
What is RBC folate level?
The majority of glucose catabolism (90%) occurs via this pathway
What is the Embden-Meyerhof pathway?
This is the most common RBC enzymopathy
What is G6PD?
This type of hemolytic anemia damages the endothelial lining of the small vessels which results in deposits of fibrin within the vessels
What is microangiopathic hemolytic anemia?
The presence of this poikilocyte in the PB could indicate G6PD deficiency
What is a blister cell?
This metabolic pathway catabolizes about 10% of the glucose essential for maintaining adequate levels of reduced glutathione
What is the hexose-monophosphate shunt (HMP)?
The primary difference between D+ and D- HUS is related to the presence of this
What is diarrhea?
This type of hemolysis characterizes an acute hemolytic transfusion reaction
What is intravascular?
What is several months after a hemolytic attack?
G6PD deficiency was first recognized during the Korean war after the administration of these drugs to soldiers
What are antimalarials?
This antibody specificity is associated with PCH
What is anti-P?
Autoantibodies associated with CAD are directed against this antigen system
What is I?
Cold autoimmune hemolytic anemia is usually caused by an antibody of this class
What is IgM?
This test can demonstrate the presence of an alloantibody
What is an antibody screen?