Anemias
A patient presents with fatigue, low ferritin, and elevated TIBC.
Iron deficiency anemia
This disorder presents with isolated thrombocytopenia, petechiae, and a normal PT/INR and aPTT.
Immune thrombocytopenia (ITP)
A 4-year-old presents with bone pain, bruising, lymphadenopathy, and refusal to walk.
Acute lymphoblastic leukemia (ALL)
A young adult presents with painless cervical lymphadenopathy, night sweats, fever, and weight loss.
Hodgkin lymphoma
The first-line treatment for iron deficiency anemia in a patient with normal GI absorption.
Oral ferrous sulfate
A patient of Mediterranean ancestry has lifelong microcytic anemia, normal ferritin, and no response to oral iron therapy.
Thalassemia
A young boy presents with recurrent hemarthroses and prolonged aPTT but a normal platelet count.
Hemophilia
A 72-year-old with asymptomatic lymphocytosis and smudge cells on peripheral smear likely has this diagnosis.
Chronic lymphocytic leukemia (CLL)
These cells are pathognomonic for Hodgkin lymphoma.
Reed-Sternberg cells
The disease-modifying therapy that reduces vaso-occlusive crises by increasing fetal hemoglobin levels in sickle cell disease.
Hydroxyurea
This laboratory finding is classically associated with lead toxicity and appears as blue granules within red blood cells.
Basophilic stippling
This is the most common bleeding manifestation seen in immune thrombocytopenia.
Petechiae
These pathognomonic inclusions on peripheral smear indicate acute myeloid leukemia.
Auer rods
This feature helps distinguish non-Hodgkin lymphoma from Hodgkin lymphoma.
Extranodal involvement
The appropriate treatment for a patient with symptomatic ITP and a platelet count of 15,000/μL.
Corticosteroids
A patient has macrocytic anemia, elevated methylmalonic acid, peripheral neuropathy, and a positive Romberg sign.
Vitamin B12 deficiency
A 68-year-old patient presents with headaches, dizziness, facial flushing, and intense itching after hot showers. Laboratory testing reveals an elevated hematocrit and low erythropoietin level.
Polycythemia Vera
This physical exam finding is particularly associated with AML and results from leukemic infiltration.
Gingival hypertrophy
The definitive diagnostic test for both Hodgkin and non-Hodgkin lymphoma.
Excisional lymph node biopsy
A patient presents with macrocytic anemia, hypersegmented neutrophils, numbness of the feet, loss of vibration sensation, and an elevated methylmalonic acid level. What is the most appropriate treatment?
Intramuscular vitamin B12
A patient with rheumatoid arthritis develops anemia with low serum iron, low TIBC, and elevated ferritin.
Anemia of chronic disease
A patient is newly diagnosed with polycythemia vera. What is the first-line treatment used to reduce blood viscosity and decrease the risk of thrombosis?
Therapeutic phlebotomy
Which leukemia is most common in middle-aged adults?
Chronic Myeloid Leukemia (CML)
Alcohol-induced lymph node pain is a highly specific but uncommon symptom associated with which type of lymphoma?
Hodgkin lymphoma
A child living in a home built before 1978 presents with developmental delays, abdominal pain, microcytic anemia, and basophilic stippling. His blood lead level is 52 μg/dL. What is the next best treatment?
Chelation therapy