Lymphoid
This translocation, if present in this subtype of gastric lymphoma, will predict a poor response to H Pylori eradication therapy
11;18, Gastric MALT lymphoma
This mutation would suggest a diagnosis of chronic neutrophilic leukemia if present
CSF3R
The immunophenotype of blastic plasmacytoid dendritic neoplasm, known by those who have heard about it before for how easy it is to memorize
CD123+ CD4 + CD56+ and CD34 negative
Mutations in this gene are most commonly implicated in ALPS
FAS
This subtype of ALL, marked by the presence of grannules more characteristically seen in myeloid blasts, is more often seen in pediatrics, and is extremely rare to find in adults with ALL
Grannular ALL
These two mutations are known to have prognostic significance in ALK negative ALCL, one which infers improved prognosis and one which infers worse prognosis
DUSP22 improved prognosis
TP63 worse prognosis
The criteria by which acute promyelocytic leukemia would be considered intermediate risk
WBC < 10 and platelets > 40
Erdheim Chester Disease can classically infiltrate this organ, leading to incessant urination
pituitary gland (diabetes insipidous)
lymphomatoid granulomatosis is often associated with this infection
EBV
Neutrophils contain myeloperoxidase and neutrophil elastase within these granules, aptly named for their central role in the frontline immune response. The latter enzyme is encoded on the ELANE gene, which when mutated, can lead to this disorder.
primary granules
Severe congenital neutropenia (or cyclic neutropenia syndrome)Perseus
The name of this drug, which targets FLT3+ AML, could be considered reminiscent of the way one would feel after doing a leg workout for the first time in years
Sorafenib (Sore AF)
When assessing the immunophenotype of an acute leukemia of ambiguous lineage, if an otherwise myeloid-phenotype leukemia co-expresses CD19, what translocation, confirming AML if present, would commonly be found?
t 8;21 (RUNX1;RUNX1T1)
Multicentric Castleman's disease is known to present with two histologic variants, and arguably a third, which is described as a mixture of the two
Hyaline vascular
plasmacytic
Mixed
Storage pool disorders can be diagnosed by confirming the absence of these on platelet electron microscopy
platelet delta granules
The mechanism of action and molecular target of the drug selinexor
selective inhibitor of nuclear export (SINE) that targets exportin 1 (XPO1)
Translocation 1;16 is recognized as being specific for this subtype of leukemia
acute erythroblastic leukemia
Vemurafenib is a therapeutic option in these two disorders, one which can cause so called hairy villous projections on lymphocytes, the other which can cause so called hairy kidneys on CT.
Hairy cell leukemia
Erdheim Chester Disease
These thresholds comprise the so-called "Camita criteria" for "very severe aplastic anemia", which is treated in the frontline setting with drug derived from the thymus of this graceful animal, along with two other drugs, one of which is immunosuppressive.
Cellularity < 25% OR 25-50% with < 30% residual hematopoetic cells
ANC < 0.2
Platelet count < 20
Retic < 20
Horse ATG
Cyclosporine
EltrombopagThis variant of APL tends to present with higher WBC and lack of Auer rods
microgranular APL
In utilizing the Hans algorithm, if one is looking at the MUM1 status of the lymphoma to decide on the GCB status of the sample, they must have already determined these other markers.
CD10 was negative and BCL6 was positive
hypereosinophilia syndrome
Mutations in this gene, the first 2 letters of whose name is reminiscent of a rock band, are implicated in families with increased risks of lymphoma, myeloid malignancies, and HLH.
U2AF1
Somatic mutations in this gene, located on this chromosome, are implicated in the development of PNH
PIGA gene, x chromosome
Plasma cells containing large cytoplasmic azurophilic grannules, have been referred to as Mott cells. The cytoplasmic inclusions of these cells have been called this name.
Russell Bodies