RBC
This is the usual MCV range in pure red cell aplasia
80 to >100 (Normo- to macrocytic)
ANC count for neutropenia
<500
Essential thrombocythemia is characterized by PLT count above this number
PLT > 450,000
This leukemia is characterized by presence of Auer rods
Acute myeloid leukemia
This type of stem cell transplant does not cause graft vs host response
Autologous hematopoietic stem cell transplant (Use in MM and lymphoma relapse)
This class of antibiotic is known to induce aplastic anemia
Beta-lactam
Name the 3 signs of Felty syndrome
Splenomegaly
Neutropenia
Rheumatoid arthritis
All patients with essential thrombocythemia should be initiated on this medication, given no absolute contraindication
Identify the 3 phases of chronic myelomonocytic leukemia
1. Chronic
2. Accelerated
3. Blast crisis
This class of medication is used to prevent neutropenia/neutropenic fever in patients receiving myelosuppressive therapy
Granulocyte colony-stimulating factors
Filgrastim (Neupogen), lenograstim
JAK2 Positive
This reaction is characterized by elevated neutrophils, left shift, metamyelocytes, usually secondary to infection
Leukemoid reactions
Name 1 genetic mutation present in essential thrombocythemia
JAK2, CALR, or MPL mutation
This vitamin is a known cure for Acute promyelocytic leukemia
All-trans retinoic acid
Target Hemoglobin level when using erythropoiesis-stimulating agent in CKD patients
Hgb 10 - 12
This infection can cause pure red cell aplasia in sickle cell patients
Parovirus B-19
This disease is characterized by leukoerythroblastic peripheral smear and "dry tap" on bone marrow biopsy
Primary myelofibrosis
This medication is used to reduce thrombosis risk in elderly patient with PCV and ET
Hydroxyurea
This class of medication is used in treatment of ALL and CML
Tyrosine kinase inhibitors (TKIs)
Imatinib, dasatinib
This side effect of stem cell transplant may be treated with TPN
Oral mucositis/severe diarrhea GI side effect
Clonal expansion of these two cells type leads to paroxysmal nocturnal hemoglobinuria
CD55- and CD59- cells
Collagen vascular disease (EGP)
Helminthic infection
Idiopathic
Neoplasia
Allergy/atopy/asthma
This mechanism can explain how patient with thrombocythemia has increase bleeding/hemorrhage risk
This medication is effective in treatment of myelodysplastic syndromes patient with 5q cytogenetic deletion
Lenalidomine
This stem cell preparative conditioning regimen confer the lowest relapse rate (MAC, NMA, RIC)
MAC: Myeloablative conditioning