Misc.
Platelet granules that release ADP and serotonin when activated.
What are dense bodies?
A bone marrow defect that results in decreased production of all cell lines (pancytopenia).
What is aplastic anemia?
Quantitative changes to globin chains.
What are thalassemias?
A lab value that will increase as the bone marrow attempts to compensate for the anemia.
What is absolute reticulocyte count?
Cells that appear as a teardrop shape.
A classic finding on wrights stain in lead poisoning.
What is basophilic stippling?
The hormone that promotes erythropoiesis.
What is erythropoietin.
95-97% HbA, 2-3% HbA2 and 1-2% HbF
What is normal adult hemoglobin?
The resulting hemolytic anemia that occurs when cells are negative for CD55 and CD59.
What is paroxysmal nocturnal hemoglobinuria?
Morphology that results from changes in membrane cation permeability.
What are stomatocytes?
A deficiency in this enzyme will result in unregulated oxidative stress and hemoglobin denaturation.
What is G6PD?
This inclusion observed on wright's stain indicates sideroblastic anemia.
What are pappenheimer bodies?
The phenomena that causes pain in sickle cell anemia.
What is vasoclusion?
A deficiency this von Willebrand factor (VWF)-cleaving protease will result in TTP?
What is ADAMTS- 13?
The characteristic morphologic feature in Hgb C disease.
What are target cells?
The condition associated with increased osmotic fragility and negative DAT
What is hereditary spherocytosis?
hemoglobin decreased; serum iron decreased; TIBC increased; ferritin decreased
What are lab values indicative of stage III IDA?
Valine is substituted for glutamic acid at the sixth position of the beta chain.
What is the point mutation responsible for sickle cell anemia?
The condition associated with; increased LDH; increased bilirubin, decreased hemoglobin, thrombocytopenia
What is TTP?
Denatured hemoglobin makes up this cellular inclusion.
What are heinz bodies?
The species that infects all red blood cells.
What is P. falciparum?
A white blood cell defect associated with megaloblastic anemias.
What are hypersegmented neutrophils?
Lab results: Normochromic normocytic anemia
Increased target cells and reticulocytes
Tetragonal crystals
What is Hgb C disease?
The common feature of all MAHA.
What is intravasular RBC fragmentation?
Associated with abetalipopreoteinemia.
What are acanthocytes?