Hemostasis
Its the disorder when GP Ib/IX/V is missing.
Bernard-Soulier Syndrome
Acute CAD (Cold autoagglutinin Disease) occurs secondary to:
mycoplasma pneumonia
Characterized by flow results that are positive for CD123 and Annexin A1
Hairy cell leukemia
4 hours
A drug that mediates anticoagulant activity by enhancing the inhibitory effects of antithrombin.
Heparin (UFH)
Vitamin K dependent coagulation factors.
II, IV, IX, X, protein C/S
Total iron- decreased
Iron binding capacity increased
% Saturation decreased
Ferritin decreased
Stage 2 IDA
Myeloperoxidase positive, Specific esterase positive and Non-specific esterase positive
Acute Myelomonocytic Leukemia
Coagulation values associated with DIC. (PT, APTT, fibrinogen, D-dimer, platelets)
PT: prolonged, PTT: prolonged, Fibrinogen: decreased, D-dimer: elevated, platelet count: decreased
10 days, 120 days
The most common factor deficiency (name and factor).
Hemophilia A (factor VIII)
In alpha thalassemia, with three inactive genes
Hemoglobin H
Expected lab values for acute leukemia.
Increased WBC, decreased H&H, decreased rbc, decreased plt. >20% blasts, normal to low retic
APTT and platelet count
Hemoglobins in a normal adult.
A, A2, F
Protein C inactivates factors ____ and ______.
Va and VIIIa
Paroxysmal nocturnal hemoglobinuria (PNH) flow cytometry results
Negative for CD55 and CD59
Disorders commonly associated with the JAK2 (V617F) mutation (3)
Essential thrombocythemia
Primary myelofibrosis
Polycythemia vera
Anisocytosis is expressed by the
RDW
The function of the methemoglobin reductase pathway
Return oxidized ferric iron to ferrous state
Explain how factor V Leiden mutation increases thrombotic risk.
Factor Va is resistant to degradation by activated protein C
The test that would rule in a definitive diagnosis of pernicious anemia.
Intrinsic factor
Characteristics of APL (MPO stain, rbc morph, wbc morph, genetics)
(MPO stain, rbc morph, wbc morph, genetics)
An increased reticulocyte production index (RPI >3) with a low hemoglobin is associated with
Hemolytic anemia
The progression of erythropoiesis from prenatal life to adulthood
yolk sac-liver and spleen-red bone marrow