Week 1
Megakaryocytes
This is a deficiency in factor 8
Hemophilia A
This can cause fever and hemolytic anemia. Typically found in northeastern and north central US. Characterized by Maltese cross on PBS.
Babesia
will also accept Ixodes tick and tick
Hodgkin's has Reed- Sternberg cells
This leads to a decrease in the synthesis of factors 2, 7, 9, and 10. It also reverses warfarin toxicity.
This drug binds gp41. (Give name and type of drug)
Enfuvirtide; fusion inhibitor
Protamine sulfate reverses this drug
heparin
67-year-old male comes in c/o fatigue. He has no other symptoms. PE shows conjunctival pallor. Labs: 9 Hb, increased TIBC, decreased ferritin, and decreased reticulocytes. PBS shows RBCs with hypochromia and microcytosis. What is the diagnosis
iron deficiency anemia due to colon cancer
will accept colon cancer or iron deficiency anemia
The translocation of 8;14 is mainly found in children. Is characterized by "Starry sky" appearance and is associated with EBV.
Burkitt lymphoma
This AIHA is associated with splenomegaly. It is due to IgG causing extravascular hemolysis. Provide the type of AIHA, if it is Coombs + or -, and how it is treated.
Warm AIHA
Coombs +
Give: prednisone, rituximab, splenectomy
This immunodeficiency characteristics cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, and hypocalcemia and is a microdeletion of 22q11
DiGeorge syndrome
Name 2 out of the 4 platelet disorders
1. Bernard- Soulier syndrome
2. Glanzmann thrombasthenia
3. Immune thrombocytopenia
4. Uremic platelet dysfunction
4 year-old comes in due to a change in behavior and abdominal pain. He lives in a home with his family that was built in 1975 in Michigan. Provide diagnosis, what the x-ray will show, what is on his gums, and how to treat.
1. lead poisoning
2. lead lines
3. Burton lines
4. in a child, chelation with succimer
Name that drug: I am a folic acid analog. I inhibit dihydrofolate reductase ultimately inhibiting DNA synthesis. I am used to treat ALL, lymphoma, and medical abortions. My ADRs are myelosuppression, pulmonary fibrosis, and nephrotoxicity.
methotrexate
This disease is characterized by a point mutation of glutamate to lycine. PBS shows crystals inside RBCs and target cells.
HbC disease
Abacavir hypersensitivity is caused by this HLA subtype?
B57
Patients were found to have abnormally large vWF multimers in their blood. Genetic analysis shows that the underlying cause is a mutation in the ADAMTS13 gene. This mutation results in a deficiency of the encoded metalloprotease, which is responsible for the cleavage of vWF. What finding on a PBS is most likely to occur?
fragmented erythrocytes
will also accept schistocytes
Affected enzymes: ferrochelatase and ALA dehydratase
Accumulated substrate: protoporphyrin and ALA
Name that drug: I am a microtubule inhibitor, interfering with cell division. I am used to treat leukemias, Hodgkin, and non-Hodgkin lymphoma. I cause neurotoxicity, peripheral neuropathy, and bone pain.
vincristine
Name the affected enzyme of AIP. Where it occurs (cytoplasm or mitochondria). Name 3 symptoms. Provide both treatments.
1. porphobilinogen deaminase
2. occurs in the cytoplasm
3. painful abdomen, port wine urine, polyneuropathy, psychological disturbances, precipitated by increased ALA synthase
4. give hemin and glucose
Explain Kehr's sign
Acute pain at the tip of the left shoulder; associated with a ruptured spleen.
1. prothrombin G20210A. Affects factor 2 (prothrombin). Increased plasma levels and venous clots.
2. Factor V Leiden. Affects factor 5 (proaccelerin). DVT, cerebral vein thrombosis, recurrent pregnancy loss.
Name the disease and provide genotype: I have a genetic condition. I had an x-ray that shows "crew cut". I require blood transfusions. I had to have a cholecystectomy because of pigmented gallstones. I had gel electrophoresis that shows 90% of HbF and 10% HbA2.
Beta- thalassemia major
B0B0
This disease is characterized by CD20, 22, 11c, and 25. Also associated with BRAF mutations. To treat, give cladribine or pentostatin.
Hairy cell leukemia
What pharyngeal pouch thymus develops, what week does it migrate, and when does it complete the migration?
1. 3rd pharyngeal pouch
2. migrates in week 5 to the thorax
3. completes migration around week 8