PBS
PBS cont.
RBC Disorders
Leukemias
NHL
HL
100
name cell type
schistocyte/helmet cell
d/t mechanical damage, shearing of rbcs
seen in MAHA, prosthetic heart valve, aortic stenosis, DIC/TTP/HUS
100
what are these inclusions? seen in hemolytic anemia and post splenectomy
Howell-Jolly Bodies
made of DNA remnants
100
what type of anemia seen with this image
sideroblastic anemia with ringed sideroblasts
100
what type of cells are these? 
blasts
100
what does green arrow represent? and what condition?
mitotic figures seen in DLBCL d/t increased proliferation
100
what CD markers do you expect to see with these cells
CD15 and CD30
Reed Sternberg cells
200
name the pathogenesis
sickle cell
d/t point mutation in beta globin gene -> aggregation of deoxy Hb
200
what are these?
stomatocytes
seen in hereditary stomatocytosis and immune hemolytic anemia
200
what disease?
malaria
200
what condition is represented here
AML
>20% blasts
200
what condition represented?
follicular lymphoma
many follicles and NO starry sky pattern
200
what kind of HL is this? and what kind of RS cells will you see?
Nodular Sclerosing Classical HL type with lacunar type RS cells
300
what is defect causing this cell type
elliptocyte
d/t RBC spectrin defect
300
what is the arrow pointing to in this cell and what does it mean?
Auer Rods
made of MPO, seen in AML
300
what type of anemia is pictured below
Iron Deficiency Anemia
small red cells with narrow rim of peripheral hemoglobin/central clearing >1/3
microcytic = rbcs are smaller than the nucleus of a small lymphocyte
300
what are the red arrows and what are they made of?
auer rods made of MPO
seen in AML
300
what condition does this represent?
bonus: what virus is this condition associated with
clover cells
seen in adult t-cell leukemia/lymphoma (ATLL)
virus: HTLV-1
300
what cell type and what condition?
Popcorn cell in Nodular Lymphocyte Predominant HL
400
causes of these cells
dacrocytes/tear drop
d/t fibrosis or metaplasia
seen in PMF/myelofibrosis, myelophthisic anemia
400
what is this, what conditions is this seen in?
rouleaux formations
seen in multiple myeloma, Waldenstrom macroglobulinemia
400
what is indicated by the arrow? what other type of cells can you see?
HbC crystal and target cells
400
what condition?
CML
<20% blasts, increased basophils
400
what are these cells and what do they represent?
hallmark or horshoe shaped cells
seen in Anaplastic Large Cell Lymphoma
500
associated conditions
target cells
seen in liver disease, thalassemia, HbC, post splenectomy
500
what are the two main causes of this cell
hypersegmented neutrophil
Folate and Vitamin B12 deficiency leads to megaloblastic anemia
500
what conditions are associated with and what immunoglobulins would you see?
cold agglutination
associated w mononucleosis, mycoplasma
IgM mediated
500
what cell and what condition
smudge cell/basket cell
seen in CLL
500
what condition is associated with these findings?
Langerhans Cell Histiocytosis
600
describe morphology and associated conditions
spherocyte
increased RDW, only true increased MCHC, lack of central pallor
seen in hereditary spherocytosis, immune hemolytic anemia
600
what does this inclusion in neutrophils indicate
leukamoid reaction >> malignancy
dohle body
600
what is the diagnosis
aplastic anemia
fat cells filling BM leads to pancytopenia
600
What is the diagnosis?
Hairy Cell Leukemia
IHC+ annexin A1, TRAP
700
what gives the this cell its shape? and what condition is it assoc w
bite cell
from macrophages "biting" out the heinz bodies in the spleen, associated w G6PD
700
what cell and what condition? what else would you expect to see on PBS or BM bx?
psuedo-Pelger Huet Cell
seen in myelodysplastic syndrome, ringed sideroblasts