Cancer Treatment
CML
CLL/Myeloproliferative
Myeloproliferative
Myeloproliferative
100
Preferred cancer staging
What is "Pathological"
100
Pathophysiology of Chromic Myelocytic Leukemia (CML)?
What is Philadelphia chromosome t(9:22)
100
Risk factors for chronic lymphocytic leukemia (CLL)?
What is positive family history and HIV
100
What is the causes for primary polycythemia vera?
What is a primary bone marrow cause, low erythropoietin, this is a clonal process (leads to excessive erythrocyte production)
100
What is essential thrombocytosis?
What is platelet count of >600,000
200
Loss of the characteristics of the originating cell type. There is more mitotic activity?
What is High grade tumor
200
Cells of myeloid line?
What is Erythrocytes, granulocytes, and platelets
200
Complications of CLL?
What is autoimmune hemolytic anemia (classic) or ITP
200
What is the common presentation of polycythemia vera?
What is pruritus after a shower or bath
200
Why do patients with essential thrombocytosis bleed?
What is they have too many platelets, which causes an acquired von willebrand disease
300
Type or targeted therapy?
What is Bcr-Abl tyrosine kinase inhibitors
300
During the plastic phase of CML what does it mean if there are more blasts?
What is more advanced stage of CML
300
Most common type of leukemia in the western world?
What is CLL
300
What drug helps to relieve erythromelelgia?
What is ASA
300
Treatment of essential thrombocytosis?
What is PDE3 inhibitor = Anagrelide (Agrylin, Xagrid)
400
Systemic therapy after complete surgical resection?
What is Neoadjuvant therapy
400
In CML is the high or low leukocyte alkaline phosphatase (LAP)?
What is low
400
Group of disorders that originate from clones of different granulocyte cell lines... neutrophils =?; RBCs =?; Platelets =?
What is CML, Polycythemia, Essential thrombocytosis
400
What is included in the major criteria for polycythemia vera?
What is Elevated RBC mass (men >36; women>32); arterial oxygen saturation >92%; splenomegaly
400
What do patients need prior to treatment with PDE 3 Inhibitor?
What is CV exam and EKG
500
Examples of myeloid growth factors?
What is Filgrastim (neupogen) and Sargramostim (Leukine)
500
Treatment of CML?
What is Tyrosine kinase inhibitors (TKIs) = Imatinib (Gleevec)
500
What is the pathophysiology of Polycythemia Vera?
What is JAK2 V617F mutation; this is the most common myeloproliferative disorder
500
Treatment of Polycythemia Vera?
What is Serial phlebotomy, ASA (erythromelelgia), and Hydroxyurea (Hydra) for pruritus
500
What is found in the peripheral smear of primary myelofibrosis? Bone marrow?
What is teardrop cells; dry tap
M
e
n
u