Mononucleosis
What is the virus that causes infectious mononucleosis?
Epstein-Barr virus
elevated hematocrit, low EPO, itching after shower, reddish discoloration of skin
nitrosoureas (carmustine, lomustine)
This AIDS-defining illness is characterized by cough, patchy bilateral infiltrates in the lungs, foamy eosinophilc material, positive silver stain
Pneumocystis jirovecii pneumonia
What should be included in your management of a patient with long face, thymic hypoplasia, cleft palate, micrognathia, hypoparathyroidism/hypocalcemia, and T-cell dysfunction?
cardiology consultation/referral
What is the clinical triad of infectious mononucleosis?
fever, pharyngitis, splenomegaly
What is the cytogenic alteration responsible for a neoplasm characterized by basophilia, low LAP, and hypercellular marrow?
t(9;22), BCR-ABL, or Philadelphia chromosome
What is the mechanism of action of the primary class of chemotherapeutics that cause cardiotoxicity?
topoisomerase II inhibition, DNA intercalation, ROS generation (anthracyclines = -RUBICINs)
efavirenz
What is the underlying defect in X-linked agammaglobulinemia?
BTK deficiency
Why is rest imperative in treating infectious mononucleosis?
risk of splenic rupture
c-myc translation, jaw or facial tumor, EBV-association, "starry sky," CD10+
Burkitt lymphoma
What is the mechanism of action of ondansetron (Zofran)?
5HT3 antagonist
Which diagnostic laboratory test will become reactive first in a clinical workup for HIV?
HIV RNA
What is the consequence of erroneously administering antibiotics for suspected strep throat in infectious mononucleosis?
dry, pruritic rash
hypercalcemia, renal failure, anemia, bone lesions, Rouleaux formation, flame cells, gammopathy/hyperviscosity, 14q32
multiple myeloma
What medications can be used to treat mucositis-related diarrhea?
loperamide, octreotide, diphenoxylate
What is the preventative treatment for toxoplasmosis?
sulfadiazine + pyrimethamine
What is the hallmark triad for Wiskott-Aldrich syndrome?
recurrent sinopulmonary infection, eczema, bleeding
What is the alternative name for a Monospot test?
heterophile antibody test
hypercalcemia, Japan or Caribbean, HTLV-1 association, cloverleaf/flower formation, CD30-, ALK-
Adult T-Cell Lymphoma/Leukemia
During which phase of the cell cycle are vinca alkaloids active during?
M-phase
A common ADE for all of the following drugs: foscarnet, cidofovir, ganciclovir, valganciclovir
nephrotoxicity
B-cell count