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Normal/high ferritin anemia with chronic disease
What is Anemia of chronic disease?
Hemolytic anemia triggered by sulfa drugs with bite cells on smear
What is G6PD deficiency?
Isolated thrombocytopenia with normal PT and aPTT after viral illness
What is Immune thrombocytopenic purpura (ITP)?
Recurrent hemarthroses with isolated prolonged aPTT
What is hemophilia?
Most common leukemia in children
What is Acute lymphoblastic leukemia (ALL)?
Low MCV anemia with ↓ ferritin and ↑ TIBC
What is Iron deficiency anemia?
Hemolysis with spherocytes, ↑ MCHC, and splenomegaly
What is Hereditary spherocytosis?
Thrombocytopenia with thrombosis 5–14 days after heparin exposure
What is Heparin-induced thrombocytopenia (HIT)?
Mucosal bleeding with impaired platelet adhesion and prolonged aPTT
What is von Willebrand disease?
Myeloid leukemia with Auer rods and t(15;17) association
What is Acute myelogenous leukemia (AML)?
Macrocytic anemia with neurologic symptoms
What is B12 deficiency?
Hemolysis with spherocytes and positive Coombs test
What is autoimmune hemolytic anemia?
Schistocytes, neurologic symptoms, and normal coagulation labs
What is Thrombotic thrombocytopenic purpura (TTP)?
Clotting factors reduced by vitamin K deficiency
What are Factors II, VII, IX, and X?
Lymphocytic leukemia with smudge cells and hypogammaglobulinemia
What is Chronic lymphocytic leukemia (CLL)?
Macrocytic anemia without neurologic symptoms
What is folate deficiency?
Schistocytes caused by intravascular RBC destruction
What is Microangiopathic hemolytic anemia?
Child with bloody diarrhea followed by anemia and renal failure
What is Hemolytic uremic syndrome (HUS)?
Most common inherited cause of venous thrombosis
What is Factor V Leiden?
Leukemia associated with t(9;22) and BCR-ABL fusion
What is Chronic myelogenous leukemia (CML)?
Microcytic anemia with target cells and normal iron studies
What is Thalassemia?
Hemolysis that improves after splenectomy due to extravascular destruction
What is Hereditary spherocytosis?
Consumptive coagulopathy with ↑ PT, ↑ aPTT, ↓ fibrinogen
What is Disseminated intravascular coagulation (DIC)?
Early warfarin therapy causing skin necrosis due to loss of this protein
What is Protein C?
Plasma cell malignancy causing CRAB symptoms and rouleaux formation
What is Multiple myeloma?