Mixed
This neonate presents with a swollen face and abdomen, hepatosplenomegaly, anemia, elevated bilirubin, and a positive direct Coombs test
What is hemolytic disease of the fetus and newborn (HDFN)?
I am a plasma cell dyscrasia characterized by abnormal proliferation of terminally differentiated B cells that produce an increased concentration of a pentameric immunoglobulin
What is Waldenstrom macroglobulinemia?
I present with Rose-colored macules "pea soup" diarrhea.
What is Salmonella typhi?
Lymph node biopsy findings show giant binucleate cells, which are CD15 & CD30 positive
What are Reed-Sternberg cells in Hodgekin Lymphoma?
I increase circulating fetal hemoglbin and am used to treat sickle cell disease
What is hydroxurea?
I convert aminolevulinic acid to make porphobilinogen
What is aminolevulinic acid dehydratase?
I present with a deficiency of factor VIII and prolonged bleeding after my tooth exraction that did not resolve with pressure and gauze packing and genetic analysis confirms an X-linked recessive disorder
What is the clinical presentation of Hemophilia A?
Patient presents with jaundice, irregular fevers, and has maltese cross pattern on the peripheral blood smear
What's the clinical presentation of Babesia?
I show heinz bodies and bite cells on my PBS
What is seen on PBS with a patient diagnosed with G6PD deficiency?
I reverse the effects of tPA by inhibiting the activation of plasminogen, thereby interfering with plasmin formation
What is the mechanism of action of aminocaproic acid and tranexamic acid?
I cleave large von Willebrand factor (vWF) multimers in the blood
What is the ADAMTS13 gene?
I have a mean corpuscular volume of 84 μm³, and serum ferritin of 475 ng/mL, and show increased levels of hepcidin and am diagnosed with rheumatoid arthritis
What is anemia of chronic disease?
I am a single-stranded, naked, and the smallest DNA virus
What are some characteristics of Parvovirus B19?
On bone marrow biopsy there is megakaryocyte hyperplasia and show clinical signs of petechiae, nosebleeds, hematuria, and isolated thrombocytopenia with normal platelet morphology
What is seen on bone marrow biopsy of immune thrombocytopenia (ITP)?
I am an anti-VEGF monoclonal antibody
What is bevacluzimab?
I am needed to convert glycine + succinyl-CoA into aminolevulinic acid
What is B6?
I've had multiple miscarriages, recurrent DVTs, and my labs show prolonged aPTT & a presence of anti-β2-glycoprotein 1 antibodies
What is antiphospholipid syndrome (APS)?
These two opportunistic fungal species mainly infects those that are immunocompromised and have diabetic ketoacidosis.
What are the Rhizopus & Mucor species?
On biopsy, I have a hypocellular bone marrow with prominent fat spaces within ("empty marrow" apperance)
What is seen on bone marrow biopsy of aplastic anemia?
Patients are cautioned against consuming large amounts of dark, leafy vegetables when taking me and PT is constantly monitored
What is warfarin?
I have EBV and am positive for t(8;14)
What is Burkitt Lymphoma?
I present with schistocytes on blood smear, decreased platelets, hematuria and proteinuria, fever, and confusion
What is the pentad of thrombotic thrombocytopenic purpura (TTP)?
This DNA virus' entry into cells is mediates by the CD21 receptor and has Downey-CD8+ cells?
What is EBV?
My cells stain positive for S-100 and on electron microscopy you see are Birbeck granules (tennis racket-shaped organelles)
What are langerhans cells?
Pathology Tie-In: clonal proliferation of these cells results in Langerhans cell histiocytosis
I am used in pregnant women to reverse coagulopathy after administration of a certain drug
What is protamine sulfate?