A lot of the first exam
Some of the second
random
Lymphomas and monoclonal gammopathy
What disease?
100
The majority of IDA in the US is due to
chronic bleeds (GI, etc)
I got this wrong on the exam :(
100
Evidence of RBC destruction and increased RBC production are hallmarks of what kind of anemia
Hemolytic anemia
100
The term "shift to the left" refers to:
Immature cell forms in peripheral blood smear
100
The presence of Reed Sternberg cells in a lymph node biopsy is diagnostic of what condition?
Hodgkin's disease (lymphoma)
100
An adult with massive splenomegaly has mild anemia, a slightly elevated WBC count,
and an LAP score of 10. These findings are most consistent with
CML
200
What RBC membrane protein is responsible for the zeta potential and ABO blood grouping
glycophorin
200
What type of WBCs would you expect to see in an uncomplicated case of infectious mononucleosis
Reactive lymphs
200
M:E ratio of 10:1 or greater is a diagnostic feature of which leukemia
CML
200
What condition is associated with increased IgM and blood hyperviscosity
Waldenstrom’s Macroglobulinemia
200
A native of Thailand has a normal hemoglobin level. Hemoglobin electrophoresis on cellulose acetate shows a 70% HbA and approximately 30% of a hemoglobin with the mobility of HbA2. This is most consistent with
hemoglobin
E trait
300
Blood cells develop from the mesodermal cells in the "blood islands" of the yolk sac during which phase of erythropoiesis?
Mesoblastic Phase
300
Hgb that is not bound to haptoglobin or excreted directly in urine is oxidized to it's ferric state which is:
Methemoglobin
300
A patient has splenomegaly, pancytopenia with majority of abnormal lymphoid cells that stain with tartrate resistant acid phosphatase (TRAP). A bone marrow aspirate could not be obtained. Which of the following is most likely?
Hairy Cell Leukemia
300
What is the cause of increased blood calcium levels in multiple myeloma?
Malignant plasma cells secreting osteoclast activating factor.
300
Congenital anemia due to inability to respond to EPO. True red blood cell aplasia
Diamond-Blackfan anemia
400
The schilling test measures what? It is diagnostic for what condition?
The GI tracts ability to absorb B-12.
Pernicious anemia.
400
The most appropriate screen test for detecting hemoglobin F is
Kleihauer-Betke
400
The presence of the chromosomal abnormality t(15;17) and a high incidence of disseminated intravascular coagulation (DIC) is diagnostic of
Acute promyelocytic leukemia (FAB-M3)
400
Flame cells and Mott cells are seen in the bone marrow of which condition?
Multiple myeloma
400
Bone marrow biopsy showing eccentric nucleus and presence of accumulation of glucocerebrosides w/ a "crinkled tissue paper" appearance
Gaucher's disease
500
90% of the glucose taken in by RBC's is metabolized using this pathway.
Embden-Meyerhof Pathway
500
This aplastic anemia is associated with megaloblastid RBCs with a normal B12 and an increased sensitivity to complement ("paroxysmal nocturnal hemoglobinuria like")
HEMPAS - hereditary erythroblastic multinuclearity with positive acidified serum
500
In normal adult bone marrow, the most common granulocyte is the
metamyelocyte
500
This type of infection may increase your risk of Hodgkin's lymphoma.
Epstein Barr infections / infectious mononucleosis (either answer acceptable)
500
Severe anemia, Hepatosplenomegaly, Skeletal deformities such as hypertrophy of cheekbones due to erythroid hyperplasia (M/E 1/20). Associated with an increased production of Hb F.
Beta thalassemia major
600
Clinical manifestations of a homozygous mutation involving the beta globin gene will most likely appear at what age?
by 6 months of age
600
Which curve represents the production of beta polypeptide chains of hemoglobin 
D
600
hydrops fetalis is associated with the the production of only this type of hemoglobin
HB barts (gamma 4)
600
What is the translocation of the non hodgkin's lymphoma considered to be very aggressive with a poor prognosis.
t(11;14) - T cell lymphoma
600
intravascular hemolytic anemia due to an RBC membrane mutation that makes cells more susceptible to lysis by complement when body pH decreases.
Paroxysmal Nocturnal Hemoglobinuria
700
The major rate limiting first step in the production of heme synthesis is
catalyzed by ALA synthase
700
Which chromosomes carry the genes required for hemoglobin
11 and 16
700
Which hemoglobin is found primarily in people from india and comigrates with HB S on cellulose acetate at alkaline pH
Hb D
700
Presence of CD2, CD5,CD 7 and absence of CD10 is associated with
T lymphocytes
700
Giant abnormal WBC granules in mutiple lineages. Abnormal platelets. Impaired chemotaxis and increased pyogenic infections. May see albinism and photosensitivity. Poor prognosis
Chediak Higashi disease