Narrow In The Marrow
Patient presents with neutropenia and anemia and workup shows low reticulocyte count. Vitamin B12 and folate levels are normal. Though you are considering to perform a bone marrow biopsy, you also to know to check for the following level.
What is Copper level?
A patient develops a deep venous thrombosis a few days after hip surgery. Hypercoagulable workup reveals a factor V leiden/ prothrombin gene mutation compound heterozygote state. He should be treated for the following duration.
What is indefinitely?
According to these criteria, those patients with cirrhosis who have a single lesion less than 5 cm or no more than three tumors all less than 3 cm qualify for liver transplantation
What are the Milan criteria?
This is the most common genetic mutation found in patients with prostate cancer.
What is BRCA2?
40 year old male with no recent drug use or liver disease presents with ecchymoses along with rectal bleeding and is found to have a platelet count of 1K with otherwise normal CBC. In addition to steroids, your consulting hematologist advises you to give the following medication to increase the platelets as rapidly as possible.
What is IVIG?
70 year old patient presents with severe pancytopenia with ANC <1000, Hgb <7, and PLT <10. Further workup reveals low reticulocyte count. Bone marrow biopsy shows bone marrow with cellularity <10% but no increase in blasts or other abnormalities. The hematologist will order for the following treatment.
What is ATG and cyclosporine?
A patient is found to have a DVT and hypercoagulable workup reveals a protein C deficiency. His hematologist will be concerned about the following complication when starting him on vitamin K antagonist therapy.
What is warfarin necrosis?
Marijuana use may be associated with an increased risk for the following form of cancer.
What is germ cell tumors?
Every male patient with this cancer, irrespective of the stage, should have genetic testing performed.
What is breast cancer?
This new intravenous medication has been shown to reduce frequency of pain events in patients with sickle cell anemia.
What is crisanlizumab?
20 year old patient presents with severe pancytopenia, also found to have a high LDH, high reticulocyte count and high bilirubin. He will be treated with the following class of medicines.
What are complement inhibitors such as eculizumab?
35 year old female presents with an acute encephalopathy and is also found to have acute renal failure, liver dysfunction and acute thrombocytopenia with platelets= 50K. Workup reveals strong titers of lupus anticoagulant, beta 2 glycoprotein and anticardiolipin. In addition to starting anticoagulation and steroids, patient will benefit from the following intervention.
What is plasma pheresis?
35 year old premenopausal female is found to have a 3 cm breast cancer s/p lumpectomy that reveals an ER+PR+Her2/neu- breast cancer with 3/13 lymph nodes. She is treated with chemotherapy followed by radiation. You start the patient on the following two classes of medications to reduce risk for cancer recurrence.
What is ovarian suppression therapy and aromatase inhibitors
A patient of northern European descent is found to have liver cirrhosis. Further workup reveals a hereditary mutation. He is likely to benefit from the following intervention.
What is phlebotomy?
The following form of extra-vascular form of hemolysis is direct coombs negative and does NOT respond to steroids or IVIG but does often respond to rituximab.
What is cold agglutinin hemolytic anemia?
A patient presents with weight loss and is found to have an enlarged spleen. Peripheral smear shows pancytopenia with a left shift, nucleated RBCs but no blasts. Bone marrow aspirate cannot be obtained but the marrow will likely stain for the following:
What is Reticulin fibrosis
This is the name of the criteria that are used to determine if a patient with cancer should be treated with prophylactic anticoagulation.
What is the Khorana criteria?
40 year old male is found to have a tongue tumor with extensive cervical lymphadenopathy. FNA of the lymph node reveals squamous cell cancer. You review the pathology report and inform him that his staging will differ depending on the results of the following stain result for the cancer.
What is P16 status/ HPV status?
35 year old female presents with gastrointestinal bleeding and colonoscopy reveals a new diagnosis of adenocarcinoma of the colon. She reports that her sister was recently diagnosed with Lynch syndrome. Her tumor is likely to be missing one of the following four proteins.
What is MSH2, MSH6, MLH1, PMS2
50 year old female with no recent drug exposures presents with headache and is found to have microangiopathic hemolytic anemia, thrombocytopenia as well as renal dysfunction. ADAMTS13 is normal. She is started on steroids and plasmapheresis without any clinical improvement. She is likely to have the following condition.
What is atypical HUS/ complement mediated TMA
50 year old male presents with dyspnea and is found to have restrictive cardiomyopathy, proteinuria and a monoclonal protein. His eyes may resemble the following animal.
What is raccoon?
This hereditary condition causes the PTT to be prolonged but is NOT typically associated with bleeding or clotting.
What is factor XII deficiency
50 year old female lifelong non-smoker of Japanese origin is found to have stage II adenocarcinoma of the lung. She has a lobectomy followed by four cycles of chemotherapy. Her oncologist later determines that her cancer has a targetable mutation and recommends that she be treated with the following medication in the adjuvant setting.
What is osimertinib or EGFR inhibitor
70 year old female presents with unexplained hematuria and recurrent ecchymoses. Labs reveal persistently elevated PTT that does not correct on 1:1 mixing studies. You consult hematology who recommends that you start her on the following medication.
What is novoseven?
50 year old male has a known longstanding history of hemolytic anemia and exam reveals splenomegaly. He has testing with direct coombs, G6PD, cold agglutinins, PNH that are all normal. He reports that one of his relatives was advised to have a splenectomy for unknown reasons. His peripheral smear will likely show the
What is spherocytes?