BMT
This 1 of the 3 purposes that HSCT can be used for and is usually done after massive doses of myeloablative chemotherapy
What is rescue HSCT?
This medication often used in conditioning regimens, requires seizure prophylaxis
What is busulfan?
This is the purpose of using several immunosuppressants in combination for solid organ transplant
What are lower doses of several agents=less toxicity + better efficacy
Calcineurin inhibitors have many drug interactions due to this commonly utilized CYP enzyme
What is CYP 3A4?
Some people call it an unregulated rapidly dividing group of cells, but you would call it an absolute contraindication of transplant
What is recent malignancy?
The historical standard of stem cell collection was from bone marrow. Now we commonly use stem cells harvested from this source
What is peripheral blood?
These are the two complications of HSCT that cause us to use immunosuppression as a preventive measure
What are HVGD and GVHD?
This is the most dangerous short-term risk associated with induction therapy
What are opportunistic infections?
This is the most common adverse effect associated with MMF use
What are GI disturbances?
This anti CD-20 monoclonal antibody is used in combination with plasmapheresis to lower the cPRA and "desensitize" the body before transplant
What is rituximab?
This method of stem cell collection comes with the highest risk of GVHD
What is peripheral blood?
This two-drug regimen is considered the “gold standard” for GVHD prophylaxis
What is calcineurin inhibitor and MTX?
This is the dose of ATG commonly given for induction therapy
What is 6mg/kg total given in several doses of 1-2mg/kg/day
This drug (that inhibits xanthine oxidase) causes a potentially dangerous drug interaction with azathioprine causing severe myelosuppression and eventually death if not caught quickly
What is allopurinol (or febuxostat)?
These two mediations are typically used to prevent CAV after cardiac transplant
What are aspirin and statins?
A patient with Hodgkin’s lymphoma would be most likely to get this type of HSCT
What is an autologous transplant?
Paliferamin is a keratinocyte growth factor used in the treatment of this complication of HSCT
What is mucositis?
A PRA of greater than this percentage would be indicative of higher immunologic risk after transplant
What is 20%?
These two symptoms are common signs of kidney transplant rejection
What are increase in SCr and decrease in urine output?
Antimicrobial prophylaxis is generally very similar across BMT and solid organ transplants except for this detail in solid organ transplant, which is generally extended
What is duration of treatment?
This “bright” chemotherapy regimen is composed of four different medications and is often used as conditioning before HSCT
What is the BEAM regimen?
This oral antibiotic is generally given 3x/week and used to prevent PJP(PCP) in allogenic transplants
What is Bactrim?
This 3-drug class regimen is considered the gold standard for maintenance therapy in solid organ transplant
What are CNI + adjuvant + Steroid
This antihypertensive drug class is preferred in transplant due to counteracting the vasoconstriction of afferent arterioles by CNIs
What are CCBs?
Due to denervation of the transplanted heart, patients may have significantly higher and variable rates of this
What is heart rate?