History
Physical Exam
Work-up
Work-up/Dx
Treatment
100
Enlarged, painless neck "lump"
What is Hodgkin disease most common presentation?
100
swelling of the face, neck (worse in supine position), cough, hoarsness
What is SVC syndrome?
100
CXR, CT (neck, chest, abdomen, pelvis), bone marrow aspiration and biopsy, PET scan
What is used to stage Hodgkin disease?
100
Waldenstrom macroglobulinemia
What is B-cell lymphoma, that secrets monoclonal IgM?
100
Vinblastine, doxorubin, bleomycin, dacarbazine
What is treatment for Hodgkin disease?
200
Increased risk of secondary cardiac events
What is estrogen and progestin therapy associated with?
200
enlarged 2 or more lymph nodes regions on the same side of diaphragm
What is stage 2 Hodgkin disease?
200
skeletal survey
What is the test to identify lytic lesions in MM?
200
Protein produced in patients with squamous cell carcinoma, causing hypercalcemia.
What is PTHrP?
200
thalidomide, dexamethasone
What is the treatment of MM?
300
Obesity, moderate-to-heavy alcohol ingestion, mantle field radiation
What is/are the risks for breast cancer?
300
Paget's disease
What is asymmetric eczema of the nipple?
300
low albumins, low AG, Rouleaux on peripheral smear
What is MM lab presentation?
300
MRI is the diagnostic procedure of choice
What is the best test to diagnose spinal cord compression?
300
monoclonal antibody that targets a growth factor receptor on the surface membrane of breast cancer cells
What is trastuzumab (Herceptin)?
400
Previous heavy exposure to pesticides
What is MGUS associated with?
400
chylous effusion
What is the type of pleural effusion in non-Hodgkin lymphoma?
400
high uric acid, K, PO4 low Ca +/- AKI
What is tumor lysis syndrome?
400
Bone marrow plasmocytosis <10%, no bony lesions, M component < 3 g/dL
What is MGUS?
400
active metabolite of tamoxifen (CYP2D6)
What is endoxifen?
500
EBV infection in patients with HIV/AIDS
What is primary CNS lymphoma, in HIV/AIDS patients associated with?
500
arrythmias, AKI, seizure
What is tumor lysis syndrome clinical presentation?
500
BRCA 2 (13q12-13)
What is the risk factor for breast ca, ovarian ca, melanoma, pancreatic and prostate ca?
500
high grade DCIS
What is comedo carcinoma?
500
Modified radical mastectomy or BCT+RT, adjuvant chemotherapy
What is treatment for 1-4 cm breast cancer , all premenopausal and HR (-) postmenopausal woman?
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