General Herpes
This type of HSV is the primary etiologic agent of herpes labialis, gingivostomatitis, and keratoconjunctivitis.
What is HSV type 1?
The sensitivity of viral culture is ...
What is low, especially for recurrent or healing lesions
Who gets HSV prophylaxis and when?
What are patients with clinical hx of genital HSV starting at 36wks
Symptoms may indicate viral shedding and thus should have c-section
What are vulvar pain or burning at delivery?
Among women with recurrent genital HSV, what % can expect at least one recurrence during pregnancy?
What is 75%?
Of these, approximately 14% of patients will have prodromal symptoms or clinical recurrence at delivery
This is the range that the the incubation period after acquisition of HSV-1 or HSV-2 is.
What is 2 days to 12 days?
What diagnostic tests are preferred for patients who present with genital vesicles, ulcers, or other mucocutaneous lesions?
What are viral culture and HSV antigen PCR
This is the dose of acyclovir and valacyclovir for a primary or first episode infection.
What are 400mg orally TID for 7-10 days, and 1g orally BID for 7-10 days?
In general, cesarean delivery is not recommended for patients with a history of HSV infection as long as...
What are no active genital lesions or prodromal symptoms present?
When is breastfeeding is contraindicated in patients with HSV?
What is active lesions on breast
During the initial infection, the virus gains access and becomes latent in this structure
What is the sensory ganglia?
These are the types of patients where type-specific serologic assays that accurately distinguish between HSV-1 and HSV-2 antibodies may be helpful.
Who are patients who have a clinical history that suggests HSV but who do not present with active lesions or whose lesions have negative culture or PCR test results?
This is the dose of acyclovir and valacyclovir for a symptomatic recurrent episode.
What is 400mg orally TID for 5 days/800 mg orally BID for 5 days, and 500mg orally BID for 3 days/1g orally daily for 5 days?
Delivery recs for women with primary or first-episode genital HSV infection anytime during the third trimester of pregnancy
Cesarean delivery may be offered due to the possibility prolonged viral shedding
Risk of vertical transmission to the neonate when a primary outbreak occurs at the time of delivery
What is approximately 40–80%
The is the incidence of new HSV-1 or HSV-2 infection during pregnancy.
What is 2%?
T/F: Routine antepartum genital HSV cultures in asymptomatic patients with history of recurrent disease is recommended
This is the dose for acyclovir and valacyclovir for daily suppression.
What is 400mg orally TID from 36 weeks until delivery and 500mg orally BID from 36 weeks until delivery.
Cesarean delivery is not recommended for women with these types of HSV lesions
What are nongenital lesions? (for example lesions on back, thigh, buttock)
A primary outbreak in the first trimester of pregnancy has been associated with?
What is neonatal chorioretinitis, microcephaly, and skin lesions in some cases
These are the classifications that neonatal HSV infections can be grouped into.
What are disseminated disease (25%); central nervous system disease (30%); and disease limited to the skin, eyes, or mouth (45%).
This type of genital herpes infection during pregnancy constitutes a higher risk of perinatal transmission
What is primary genital herpes infection?
Treatment for severe disseminated disease
what is IV acyclovir q8h for 2-7 days followed by oral therapy to complete 10 days
Rec management of patients with active genital HSV lesions or prodromal symptoms and PPROM
What is there is no consensus for GA for delivery at which the risks of prematurity outweigh the risks of HSV.
When expectant management is elected, treatment with an antiviral is recommended. The decision to use corticosteroids should be based on the balance between the risk of pulmonary immaturity and the risk of neonatal herpes.
Percentage of infants infected with neonatal herpes among patients with HSV isolated from genital secretions at delivery (CS vs NSVD)
What is 1.2% of infants delivered by cesarean birth compared with 7.7% of infants delivered vaginally