Name this condition
generalized eruptive histiocytoma
Name this tumor
Acral fibrokeratoma
Are this patient's lipid levels normal, low, or high?
Normal
What is this tumor?
Name this condition
Infantile myofibromatosis
- Most common of the juvenile fibromatoses; high mortality with involvement of viscera
- usually on head, neck, or trunk
- skeletal involvement in 50%
- cutaneous + skeletal involvement= good prognosis, regress spontaneously
- high mortality rate with visceral involvement
What makes it "indeterminate" cell histiocytosis?
Antigenic markers of both LCH (S100+, CD1a+) and non-LCH (CD68+, CD163+), BUT Langerin (CD207)-negative
Aside from tuberous sclerosis, what other 2 genetic conditions are associated with multiple angiofibromas of the face?
MEN type I
Burt-Hogg-Dube
Possible trigger for this condition?
mycobacteria
Diagnosis?
(Cellular) neurothekoma
Most common site of nodular fasciitis in adults?
Upper arms
bone
lung
skin
Name 2 subtypes of adult fibromatosis
–Palmar fibromatosis (Dupuytren's disease
–Plantar fibromatosis (Ledderhose's disease)
–Penile fibromatosis (Peyronie's disease)
–Knuckle pads (holoderma)
–Pachydermodactyly
What 2 conditions are associated with JXGs?
NF1
JMML
What syndrome is associated with this tumor?
MEN II
This tumor can affect prior burn/ radiation tx sites
Fibrosarcoma
What lab finding is the hallmark feature of this disease?
IgG monoclonal gammopathy
What gene mutation is associated with this lesion?
PTEN
What condition can patients with benign cephalic histiocytosis develop?
diabetes insipidus
Classic pathology finding for this lesion?
Verocay bodies (Schwannoma)
Where do epithelioid sarcomas usually present?
distal extremities (usually hands, fingers
Name the 4 Langerhan's cell histiocytoses
Hand-Schuller-Christian: early lesions similar to Letterer- Siwe; late lesions more xanthomatous & can have ulcerative nodules
Compared to DFSP, what 2 stains does a dermatofibroma stain positive for and what 1 stain does it stain negative for?
Positive: Factor XIIIA, stromeolysin
Negative: CD34
What gene mutation is responsible for the rare familial form of this patient's condition (associated with massive, painless bilateral cervical lymphadenopathy)?
SLC29A3 -> encodes an equilibrative nucleoside transporter hENT3
What stain is positive for this growth?
CK20- merkel cell carcinoma
CK20 with perinuclear dot pattern
This condition stains positive to 4 stains- name 2 of them
Vimentin, CD10, CD99, CD68