They Came, They Saw, They Inflamed
Fibrous follies
Histio holiday
Tumor NOS
Fibrous & furious
100
Name this condition
generalized eruptive histiocytoma
100
Name this tumor
Acral fibrokeratoma
100
Are this patient's lipid levels normal, low, or high?
Normal
100
What is this tumor?
100
Name this condition
Infantile myofibromatosis
- Most common of the juvenile fibromatoses; high mortality with involvement of viscera
- usually on head, neck, or trunk
- skeletal involvement in 50%
- cutaneous + skeletal involvement= good prognosis, regress spontaneously
- high mortality rate with visceral involvement
200
What makes it "indeterminate" cell histiocytosis?
Antigenic markers of both LCH (S100+, CD1a+) and non-LCH (CD68+, CD163+), BUT Langerin (CD207)-negative
200
Aside from tuberous sclerosis, what other 2 genetic conditions are associated with multiple angiofibromas of the face?
MEN type I
Burt-Hogg-Dube
200
Possible trigger for this condition?
mycobacteria
200
Diagnosis?
(Cellular) neurothekoma
200
Most common site of nodular fasciitis in adults?
Upper arms
300
Most common sites of LCH in adults (3)
bone
lung
skin
300
Name 2 subtypes of adult fibromatosis
–Palmar fibromatosis (Dupuytren's disease
–Plantar fibromatosis (Ledderhose's disease)
–Penile fibromatosis (Peyronie's disease)
–Knuckle pads (holoderma)
–Pachydermodactyly
300
What 2 conditions are associated with JXGs?
NF1
JMML
300
What syndrome is associated with this tumor?
MEN II
300
This tumor can affect prior burn/ radiation tx sites
Fibrosarcoma
400
What lab finding is the hallmark feature of this disease?
IgG monoclonal gammopathy
400
What gene mutation is associated with this lesion?
PTEN
400
What condition can patients with benign cephalic histiocytosis develop?
diabetes insipidus
400
Classic pathology finding for this lesion?
Verocay bodies (Schwannoma)
400
Where do epithelioid sarcomas usually present?
distal extremities (usually hands, fingers
500
Name the 4 Langerhan's cell histiocytoses
Hand-Schuller-Christian: early lesions similar to Letterer- Siwe; late lesions more xanthomatous & can have ulcerative nodules
500
Compared to DFSP, what 2 stains does a dermatofibroma stain positive for and what 1 stain does it stain negative for?
Positive: Factor XIIIA, stromeolysin
Negative: CD34
500
What gene mutation is responsible for the rare familial form of this patient's condition (associated with massive, painless bilateral cervical lymphadenopathy)?
SLC29A3 -> encodes an equilibrative nucleoside transporter hENT3
500
What stain is positive for this growth?
CK20- merkel cell carcinoma
CK20 with perinuclear dot pattern
500
This condition stains positive to 4 stains- name 2 of them
Vimentin, CD10, CD99, CD68
