Antiretroviral therapy is recommended in all HIV infected individuals. Exception maybe be made if...
What is patient is not willing or able to commit to treatment
100
These are the 6 classes of antiretrovirals.
What are NRTI, NNRTI, PI, ISTI, Entry inhibiors (fusion inhibitors and CCR5 antagonists), Pharmacokinetic enhancers?
100
Atazanavir/ritonavir + tenofovir/emtricitabine was removed from the guidelines as a preferred regimen because of this reason.
What is greater rate of toxicities (increased discontinuation in clinical trials)?
100
Atazanavir
What is Reyataz?
100
Lopinavir/ritonavir
What is Kaletra?
200
These are two benefits of maintaining undetectable viral loads.
What is improved immune function, improved quality of life, lowers risk of AIDS defining and non AIDS defining conditions, prolonged life?
200
Initial therapy for a treatment naive patient should include 2 agents from which class?
What is NRTI?
200
This is the reason efavirenz/tenofovir/emtricitabine was removed from the preferred guideline list.
What is high rate of CNS toxicity specifically suicidality?
200
Darunavir
What is Prezista?
200
Abacavir
What is Ziagen?
300
These are 2 non AIDS defining complications that can be prevented by suppressing viral load.
What is HIV associated nephropathy, Co-infection with Hep B and C, Cardiovascular disease, malignancies, neurological complications
300
In addition to 2 NRTI these are the 3 classes that can be used in combination for initial therapy.
What is ISTI, PI, NNRTI? These are included in both first line an alternative therapy. Which 2 are considered first-line?
300
This is the only PI based regimen currently recommended as preferred in the guidelines.
What is darunavir/ritnoavir + tenofovir/emtricitabine?
300
Ritonavir
What is Norvir?
300
Dolutegravir
What is Tivicay?
400
These are two concerns regarding early initiation of therapy.
What are drug toxicities, impact on quality of life, non-adherence, early development of resistance, cost?
400
Selection of initial therapy should take into consideration the following: (name 3)
What are efficacy, toxicity, pill burden, dosing frequency, drug interactions, resistance testing, comorbid conditions, cost?
400
Cobicistat is available coformulated with which PIs (2).
What are Atazanavir and Darunavir?
400
Tenofovir
What is Viread?
400
Efavirenz
What is Sustiva?
500
These are 3 conditions favoring urgent initiation of therapy.
What are Pregnancy, AIDS defining conditions, Acute OI, HIVAN, Low CD4 count, Acute/early infection, Hep B/C coinfection, Rapidly declining CD4 counts, High viral load?
500
These are the two pharmacokinetic enhancers.
What are ritonavir and cobicistat?
500
List 2 advantages of choosing an INSTI regimen as initial therapy.
What are high efficacy, excellent safety/tolerability, low number of drug-drug interactions?