NRTIs
What does NRTI stand for?
What are nucleoside reverse transcriptase inhibitors?
What does NNRTI stand for?
What is non-nucleoside reverse transcriptase inhibitor?
Are protease inhibitors recommended as initial therapy?
No
Where are CCR5 receptors found? (3)
Macrophages, dendritic cells, T-cells
ART therapy is given to patients with ____
What is HIV?
What enzyme do NRTIs inhibit?
What is reverse transcriptase?
NNRTIs bind to reverse transcriptase using ____ inhibition
When would you recommend protease inhibitors to a patient?
If they are at risk for poor adherence
What kind of test is required before prescribing Maravoric or Enfuvirtide?
Tropism test
What category of ART is always given in combination therapy?
What is NRTI?
NRTIs work by competitively binding to reverse transcriptase enzymes. How do they do this?
Structural analogs of nucleoside bases that lack a 3' hydroxyl group are inserted into DNA chain.
Are NNRTIs recommended for initial therapy?
No
What suffix do protease inhibitors end in?
-navir
Enfuvirtide is an antagonist of what?
What is GP41?
When should you begin prophylactic HIV therapy?
The sooner the better. (Generally before CD4 counts are below 300)
What drug is Abacavir commonly paired with?
What is Lamivudine?
NNRTIs are not recommended for first line therapy for what reason? (Name 1)
-Large side effects
-Virologic failure more common
Why are protease inhibitors never used as monotherapy?
What drug blocks the binding of CCR5 and GP120?
What is a major side effect of Abacavir and what test needs to be done as a result?
What is the only NRTI that is a nucleotide rather than a nucleoside?
What is Tenofovir?
Name 2 drugs in this class
What are Efavirenz, Delavirdine, Nevirapine?
What enzyme do protease inhibitors inhibit, leading to significant drug-drug interactions?
What is CYP3A4?
What is the name of the humanized monoclonal antibody in this drug class?
What is Ibalizumab?
Tenofovir disoproxil fumarate (TDF) can lead to renal function and bone mineral density. What is recommended instead to reduce these effects?
Tenofovir alafenamide (TAF)- prodrug with 91% less circulating plasma tenofovir