Drug Me Up
Diabetes drug that causes weight gain, heart failure, and peripheral edema
Thiazolidinediones (TZDs)/Glitazones
MOA: binds PPAR-gamma intranuclear receptor -> increase insulin sensitivity
3 enzymes that require 5 special cofactors
Pyruvate DH Complex, Alpha-ketoglutarate DH, Transketolase
Cofactors: Tender Love and Care For Nancy
"TPP, Lipoic Acid, CoA, FAD, NAD"
27 y/o female with amenorrhea and white nipple discharge from both breasts
Acts via a toxin acts by inactivating the 60S ribosome by removing adenine from rRNA. It does not invade host cells.
EHEC 0157:H7
Shiga-like toxin/Vera toxin
Best drug to treat Graves ophthalmopathy
Glucocorticoids
Deficiency causes triad of episodic peripheral neuropathy, angiokeratomas, hypohidrosis. Late progression leads to renal failure and cardiovascular disease
Alpha-Galactosidase A (Fabry Disease)
X-Linked
Buildup of Ceramide Trihexoside
"A FABulous alpha male breaks the hearts of 3 women by peeing on them"
First line treatment for SIADH
"-vaptan" drugs (conivaptan, tolvaptan)
MOA: V2 ADH receptor antagonist
Pt with poor exercise endurance, severe muscle cramping and urine discoloration. Exercise tolerance improved greatly w/ oral glucose solution before activity
(+150 - correct enzyme, +150 - name of disease)
Myophosphorylase (Glycogen Phosphorylase isozyme in muscle) Deficiency
Type V: McArdle disease
2 diabetes drugs that DO NOT cause hypoglycemia
GLP-1 analogs and DDP-4 inhibitors
MOA: stimulate pancreas sensitivity to glucose -> increase insulin release
2 drugs that act on the area postrema (+150 per correct drug name)
Receptor that drugs on and if agonist/antagonist (+100 per correct receptor)
Metoclopramide (D2 antagonist)
Aprepitant (NK1 receptor antagonist)
Child with poor feeding, vomiting and lethargy. Diapers smell of "burnt sugar". Pt shows generalized hypertonia on PE.
Branched Chain Alpha Ketoacid DH (BCAKD)
Pt has Maple Syrup Urine Disease. Avoid Branched Amino Acids (Val, Ile, Leu)